Recombinant Allergen Immunotherapy: Clinical Evidence of Efficacy—A Review

被引：0
作者：
Melina Makatsori
Oliver Pfaar
Ramon Lleonart
Moises A. Calderon
机构：
[1] NHLI,Section of Allergy and Clinical Immunology, Imperial College London
[2] Royal Brompton Hospital,Centre for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery
[3] University Hospital,Allergy Unit, Internal Medicine Department
[4] Hospital Universitari de Bellvitge,undefined
来源：
Current Allergy and Asthma Reports | 2013年 / 13卷
关键词：
Allergy; Rhinitis; Asthma; Recombinants; T-cell epitopes; Wild-type recombinants; Modified/hypoallergen allergens; Fusion proteins; Cat; Grass; Birch; Ragweed; Venom allergy; Immunotherapy; Efficacy;
D O I：
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中图分类号：
学科分类号：
摘要：
Recombinant allergens for immunotherapy aim to overcome the problems of natural extracts as they can be produced in unlimited amounts with exact physiochemical and immunological properties. These can be modified to have more favourable characteristics including reduced IgE reactivity or enhanced immunogenicity. Different types of recombinant allergens have been evaluated in clinical phase II and III trials whilst others are currently under development. In this review, we identified double-blind, placebo-controlled randomised clinical trials assessing the efficacy and safety of various recombinant allergen preparations. The majority of studies have up to now focused on cat, grass, birch, ragweed and bee venom allergens. Some studies have shown some of these preparations to be effective and well tolerated. However, there are still outstanding issues regarding optimum doses, minimising side effects and long-term effects.
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页码：371 / 380
页数：9
相关论文
共 197 条
[1]  
Abramson MJ(2010)Injection allergen immunotherapy for asthma Cochrane Database Syst Rev 8 351-8
[2]  
Puy RM(2007)Allergen injection immunotherapy for seasonal allergic rhinitis Cochrane Database Syst Rev 1 30-7
[3]  
Weiner JM(2000)Effectiveness of specific immunotherapy in the treatment of hymenoptera venom hypersensitivity: a meta-analysis Clin Ther 22 1263-72
[4]  
Calderon MA(2010)Specific immunotherapy using Hymenoptera venom: systematic review Sao Paulo Med J 128 178-95
[5]  
Alves B(2012)Venom immunotherapy for preventing allergic reactions to insect stings Cochrane Database Syst Rev 10 555-63
[6]  
Jacobson M(2010)Sublingual immunotherapy for allergic rhinitis Cochrane Database Syst Rev 12 601-16
[7]  
Hurwitz B(2011)Sublingual immunotherapy for allergic conjunctivitis: Cochrane systematic review and meta-analysis Clin Exp Allergy 41 865-72
[8]  
Sheikh A(2013)New directions in immunotherapy Curr Allergy Asthma Rep 13 826-30
[9]  
Durham S(2012)Safety of engineered allergen-specific immunotherapy vaccines Curr Opin Allergy Clin Immunol 12 860-4
[10]  
Ross RN(2012)Subcutaneous allergen immunotherapy for allergic disease: examining efficacy, safety and cost-effectiveness of current and novel formulations Immunotherapy 4 575-581
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