Analgesic efficacy and clinical acceptability of adjunct pre-emptive intravenous tramadol in midazolam sedation for third molar surgery

被引：4

作者：

Eriksson L. ^{[1
]}

Tegelberg Å. ^{[2
]}

机构：

[1] Department of Oral and Maxillofacial Surgery, County Hospital, Falun, 791 82, Falu Lasarett

[2] Department of Stomatognathic Physiology, Faculty of Odontology, Malmö University, Malmö

来源：

Oral and Maxillofacial Surgery | 2013年 / 17卷 / 3期

关键词：

Midazolam; Pain; Postoperative analgesia; Third molar surgery; Tramadol;

D O I：

10.1007/s10006-012-0359-0

中图分类号：

学科分类号：

摘要：

Introduction: This study aims to compare two routine procedures of sedation, with and without intravenous adjunct analgesia, in third molar surgery regarding postoperative pain and consumption of analgesics. Material and methods: In a randomized, controlled, single-blinded procedure, 87 men and women aged 18-44 years were divided into two treatment groups, midazolam + tramadol (M + T) and midazolam + saline (M + S), and one control group (C), with no additional medication. After removal of a third lower molar, patients recorded postoperative pain on a visual analog scale (VAS) and consumption of analgesics during the first day after surgery. Results: Time from the end of operation until first rescue pill (400 mg Ibuprofen tablet) differed significantly between the M + S group (193 min) and the C group (110 min) (p = 0.001) as well as the M + T group (157 min) and the C group (p = 0.049). The study did not show any significant reduction of postoperative pain, VAS, after third molar surgery in patients who received adjunct pre-emptive intravenous administration of 1 mg/kg tramadol under midazolam sedation. Discussion and conclusion: The lack of significant difference between the study and placebo groups indicates that tramadol at 1 mg/kg might be an insufficient dose, though the suitability for tramadol in oral and maxillofacial surgery has already been settled in other studies. © 2012 Springer-Verlag.

引用

页码：193 / 199

页数：6

共 38 条

[1]

Liedholm R., Mandibular Third Molar Removal. Thesis, (2005)

[2]

Seymore R.A., Meechan J.G., Blair G.S., An investigation into postoperative pain and third molar surgery under local analgesia, Br J Oral Maxillofac Surg, 23, pp. 410-418, (1985)

[3]

Fischer S.E., McEntegart D.J., Factors affecting the onset and severity of pain following the surgical removal of unilateral impacted mandibular third molar teeth, Br Dent J, 164, pp. 351-354, (1988)

[4]

Henning Abrahamsson K., Dental Fear and Oral Health Behavior. Thesis, (2003)

[5]

Thomson W.M., Locker D., Poulton R., Incidence of dental anxiety in young adults in relation to dental treatment experience, Comm Dent Oral Epidemiol, 28, pp. 289-294, (2000)

[6]

Meechan J.G., Seymour R.A., The use of third molar surgery in clinical pharmacology, Br J Oral Maxillofac Surg, 31, pp. 360-365, (1993)

[7]

Lundgren S., Sedation Regimen in Outpatient Oral Surgery. Thesis, (1985)

[8]

Rune J., Strom C., Midazolam intravenous conscious sedation in oral surgery, Swed Dent J, 20, pp. 29-33, (1996)

[9]

Roelofse J.A., van der Bijl P., Cardiac dysrhythmias associated with intravenous lorazepam, diazepam and midazolam during oral surgery, J Oral Maxillofac Surg, 52, pp. 247-250, (1994)

[10]

Dionne R.A., Yagiela J.A., More P.A., Gonty A., Zuniga J., Beirne R., Comparing efficacy and safety of four intravenous sedation regimens in dental outpatient, Jada, 132, pp. 740-750, (2001)

← 1 2 3 4 →