Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

被引：0
|
作者：
Yun-Jun Liu
Cheng-Hui Zeng
机构：
[1] Guangdong Pharmaceutical University,School of Pharmacy
来源：
Transition Metal Chemistry | 2009年 / 34卷
关键词：
Ruthenium; Phen; Thermal Denaturation; Isatin; Absorption Titration;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The binding of the ruthenium(II) complexes [Ru(bpy)2(ITAP)](ClO4)2 (bpy = 2,2’-bipyridine) and [Ru(phen)2(ITAP)](ClO4)2 (phen = 1,10-phenanthroline, ITAP = isatino[1,2-b]-1,4,8,9-tetraazatriphenylene) to calf thymus DNA (CT-DNA) have been investigated with UV–visible and emission spectroscopy, viscosity measurements, thermal denaturation, and photoactivated cleavage. The experimental results indicate that the two complexes bind to CT-DNA through an intercalative mode. The two Ru(II) complexes in the presence of plasmid pBR322 DNA have been found to give rise to nicking of DNA upon irradiation.
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页码：455 / 462
页数：7
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