Lipophilic Imidazolylpyridines with Antimicrobial Activity

被引：0
|
作者：
T. S. Vedekhina
M. Z. Dogonadze
T. I. Vinogradova
M. V. Chudinov
A. Yu. Lukin
机构：
[1] Federal Medical Biological Agency,Lopukhin Federal Research and Clinical Center of Physical
[2] St. Petersburg State Research Institute of Phthisiopulmonology,Chemical Medicine
[3] Ministry of Health of Russia,undefined
[4] Lomonosov Institute of Fine Chemical Technologies,undefined
[5] MIREA – Russian Technological University,undefined
来源：
Pharmaceutical Chemistry Journal | 2023年 / 57卷
关键词：
lipophilicity; imidazolylpyridines; zinc triflate; antimicrobial activity; antituberculosis activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The reaction of nicotinic and isonicotinic propargylamides with lipophilic aliphatic amines yielded a series of 3- or 4-(5-methyl-1H-imidazol-2-yl)pyridines containing a lipophilic substituent in the imidazole ring 1-position. The new compounds were characterized by physicochemical methods. The antituberculosis and antimicrobial activities against ESKAPE pathogens were studied. 3-[1-(1-n-Octadecyl)-5-methyl-1Himidazol-2-yl]pyridine (IIId) had antituberculosis activity (MIC 6.2 μg/mL) while 3-[1-(1-adamantylmethyl)-5-methyl-1H-imidazol-2-yl]pyridine (IIIa) exhibited activity against S. aureus (MIC 16 μg/mL).
引用
收藏
页码：816 / 821
页数：5
相关论文
共 50 条
  • [41] Antimicrobial activity of Evodia elleryana
    Khan, MR
    Kihara, M
    Omoloso, AD
    FITOTERAPIA, 2000, 71 (01) : 72 - 74
  • [42] Antimicrobial Activity of Naphthyridine Derivatives
    Wojcicka, Anna
    Maczynski, Marcin
    PHARMACEUTICALS, 2024, 17 (12)
  • [43] Antimicrobial activity of ozonated water
    Bialoszewski, Dariusz
    Bocian, Ewa
    Bukowska, Bozena
    Czajkowska, Magdalena
    Sokol-Leszczynska, Beata
    Tyski, Stefan
    MEDICAL SCIENCE MONITOR, 2010, 16 (09): : MT71 - MT75
  • [44] Antimicrobial activity of ten Lycoperdaceae
    Dulger, B
    FITOTERAPIA, 2005, 76 (3-4) : 352 - 354
  • [45] Antimicrobial activity of Ficus species
    Shivani
    Navneet
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION B-BIOLOGICAL SCIENCES, 2010, 80 : 332 - 335
  • [46] Antimicrobial activity in bacterial biofilms
    Rodriguez-Martinez, Jose Manuel
    Pascuala, Alvaro
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2008, 26 (02): : 107 - 114
  • [47] Antimicrobial activity of Cassia alata
    Khan, MR
    Kihara, M
    Omoloso, AD
    FITOTERAPIA, 2001, 72 (05) : 561 - 564
  • [48] Peptides and proteins with antimicrobial activity
    Melo Coutinho, Henrique Douglas
    Lobo, Katiuscia Menezes
    Casimiro Bezerra, Denise Aline
    Lobo, Inalzuir
    INDIAN JOURNAL OF PHARMACOLOGY, 2008, 40 (01) : 3 - 9
  • [49] Antimicrobial activity of Harpullia ramiflora
    Khan, MR
    Kihara, M
    Omoloso, AD
    FITOTERAPIA, 2001, 72 (03) : 298 - 300
  • [50] Antimicrobial activity of Plicosepalus acaciae
    Elegami, AA
    Elnima, EI
    Muddathir, AK
    Omer, ME
    FITOTERAPIA, 2001, 72 (04) : 431 - 434
12345