Lipophilic Imidazolylpyridines with Antimicrobial Activity

被引：0
|
作者：
T. S. Vedekhina
M. Z. Dogonadze
T. I. Vinogradova
M. V. Chudinov
A. Yu. Lukin
机构：
[1] Federal Medical Biological Agency,Lopukhin Federal Research and Clinical Center of Physical
[2] St. Petersburg State Research Institute of Phthisiopulmonology,Chemical Medicine
[3] Ministry of Health of Russia,undefined
[4] Lomonosov Institute of Fine Chemical Technologies,undefined
[5] MIREA – Russian Technological University,undefined
来源：
Pharmaceutical Chemistry Journal | 2023年 / 57卷
关键词：
lipophilicity; imidazolylpyridines; zinc triflate; antimicrobial activity; antituberculosis activity;
D O I：
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中图分类号：
学科分类号：
摘要：
The reaction of nicotinic and isonicotinic propargylamides with lipophilic aliphatic amines yielded a series of 3- or 4-(5-methyl-1H-imidazol-2-yl)pyridines containing a lipophilic substituent in the imidazole ring 1-position. The new compounds were characterized by physicochemical methods. The antituberculosis and antimicrobial activities against ESKAPE pathogens were studied. 3-[1-(1-n-Octadecyl)-5-methyl-1Himidazol-2-yl]pyridine (IIId) had antituberculosis activity (MIC 6.2 μg/mL) while 3-[1-(1-adamantylmethyl)-5-methyl-1H-imidazol-2-yl]pyridine (IIIa) exhibited activity against S. aureus (MIC 16 μg/mL).
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页码：816 / 821
页数：5
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