Ubiquitin-mediated NFκB degradation pathway

被引：0
|
作者：
Huimin Xu
Mengli You
Haifeng Shi
Yongzhong Hou
机构：
[1] Institute of Life Sciences,
[2] Jiangsu University,undefined
来源：
Cellular & Molecular Immunology | 2015年 / 12卷
关键词：
NFκB; ubiquitination; degradation; pathway;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The nuclear factor κB (NFκB) transcription factor plays critical roles in inflammation and immunity. The dysregulation of NFκB is associated with inflammatory and autoimmune diseases and cancer. NFκB activation is negatively regulated by the ubiquitin-dependent proteasomal degradation pathway. In the present review, we discuss recent advances in our understanding of how ubiquitin ligases regulate the NFκB degradation pathway.
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页码：653 / 655
页数：2
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