Ubiquitin-mediated NFκB degradation pathway

被引：0
|
作者：
Huimin Xu
Mengli You
Haifeng Shi
Yongzhong Hou
机构：
[1] Institute of Life Sciences,
[2] Jiangsu University,undefined
来源：
Cellular & Molecular Immunology | 2015年 / 12卷
关键词：
NFκB; ubiquitination; degradation; pathway;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The nuclear factor κB (NFκB) transcription factor plays critical roles in inflammation and immunity. The dysregulation of NFκB is associated with inflammatory and autoimmune diseases and cancer. NFκB activation is negatively regulated by the ubiquitin-dependent proteasomal degradation pathway. In the present review, we discuss recent advances in our understanding of how ubiquitin ligases regulate the NFκB degradation pathway.
引用
收藏
页码：653 / 655
页数：2
相关论文
共 50 条
  • [1] Ubiquitin-mediated NFκB degradation pathway
    Xu, Huimin
    You, Mengli
    Shi, Haifeng
    Hou, Yongzhong
    CELLULAR & MOLECULAR IMMUNOLOGY, 2015, 12 (06) : 653 - 655
  • [2] Regulation of the TGFβ signalling pathway by ubiquitin-mediated degradation
    Izzi, L
    Attisano, L
    ONCOGENE, 2004, 23 (11) : 2071 - 2078
  • [3] Regulation of the TGFβ signalling pathway by ubiquitin-mediated degradation
    Luisa Izzi
    Liliana Attisano
    Oncogene, 2004, 23 : 2071 - 2078
  • [4] The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications
    Burger, AM
    Seth, AK
    EUROPEAN JOURNAL OF CANCER, 2004, 40 (15) : 2217 - 2229
  • [5] THE UBIQUITIN-MEDIATED PROTEOLYTIC PATHWAY
    CIECHANOVER, A
    BRAIN PATHOLOGY, 1993, 3 (01) : 67 - 75
  • [6] Ubiquitin-mediated regulation of NF-κB activation and autophagy
    Dikic, I.
    FEBS JOURNAL, 2010, 277 : 10 - 11
  • [7] Regulation of Cidea protein stability by the ubiquitin-mediated proteasomal degradation pathway
    Chan, Siu Chiu
    Lin, Sheng-Cai
    Li, Peng
    BIOCHEMICAL JOURNAL, 2007, 408 (259-266) : 259 - 266
  • [8] Ubiquitin-Mediated Degradation of Aurora Kinases
    Lindon, Catherine
    Grant, Rhys
    Min, Mingwei
    FRONTIERS IN ONCOLOGY, 2016, 5
  • [9] Ubiquitin-mediated degradation at the Golgi apparatus
    Buzuk, Lana
    Hellerschmied, Doris
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2023, 10
  • [10] UBIQUITIN-MEDIATED PROTEIN MODIFICATION AND DEGRADATION
    SCHWARTZ, AL
    CIECHANOVER, A
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1992, 7 (05) : 463 - 468
12345