Effects of the peripherally acting μ-opioid receptor antagonist methylnaltrexone on acute pancreatitis severity: study protocol for a multicentre double-blind randomised placebo-controlled interventional trial, the PAMORA-AP trial

被引：0
作者：
Cecilie Siggaard Knoph
Mathias Ellgaard Cook
Camilla Ann Fjelsted
Srdan Novovic
Michael Bau Mortensen
Liv Bjerre Juul Nielsen
Mark Berner Hansen
Jens Brøndum Frøkjær
Søren Schou Olesen
Asbjørn Mohr Drewes
机构：
[1] Aalborg University Hospital,Mech
[2] Aalborg University,Sense, Department of Gastroenterology & Hepatology
[3] Gastrounit,Department of Clinical Medicine
[4] Copenhagen University Hospital Hvidovre,Odense Pancreas Centre, HPB Section, Department of Surgery
[5] Odense University Hospital,Digestive Disease Centre K, Bispebjerg Hospital
[6] University of Copenhagen,Mech
[7] Aalborg University Hospital,Sense, Department of Radiology
来源：
Trials | / 22卷
关键词：
Methylnaltrexone; Opioid antagonists; Drug antagonism; Acute pancreatitis; Treatment; Randomised controlled trial;
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  • [1] Kirkegård J(2020)Predictors of underlying pancreatic cancer in patients with acute pancreatitis: a Danish nationwide cohort study HPB. 22 553-562
  • [2] Mortensen FV(2017)The incidence and aetiology of acute pancreatitis across Europe Pancreatology. 17 155-165
  • [3] Heide-Jørgensen U(2010)Organ failure and infection of pancreatic necrosis as determinants of mortality in patients with acute pancreatitis Gastroenterology. 139 813-820
  • [4] Cronin-Fenton D(2019)Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis Gut. 68 1044-1051
  • [5] Roberts SE(2015)Acute pancreatitis Lancet (London, England) 386 85-96
  • [6] Morrison-Rees S(2009)Early systemic inflammatory response syndrome is associated with severe acute pancreatitis Clin Gastroenterol Hepatol. 7 1247-1251
  • [7] John A(2013)Comparison of Ranson, Glasgow, MOSS, SIRS, BISAP, APACHE-II, CTSI Scores, IL-6, CRP, and procalcitonin in predicting severity, organ failure, pancreatic necrosis, and mortality in acute pancreatitis HPB Surg. 2013 1-10
  • [8] Williams JG(2017)Persistent systemic inflammatory response syndrome predicts the need for tertiary care in acute pancreatitis Acta Gastroenterol Belg. 80 377-380
  • [9] Brown TH(2013)IAP/APA evidence-based guidelines for the management of acute pancreatitis Pancreatology. 13 e1-15
  • [10] Samuel DG(2005)The endogenous opioid system and clinical pain management AACN Clin Issues. 16 291-301
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