Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

被引：0
作者：
Kuan-Ming Chen
Elena Harjes
Phillip J. Gross
Amr Fahmy
Yongjian Lu
Keisuke Shindo
Reuben S. Harris
Hiroshi Matsuo
机构：
[1] Molecular Biology and Biophysics,Department of Biochemistry
[2] Institute for Molecular Virology and,Department of Biological Chemistry and Molecular Pharmacology
[3] ,undefined
[4] Arnold and Mabel Beckman Center for Genome Engineering,undefined
[5] University of Minnesota,undefined
[6] Minneapolis,undefined
[7] Minnesota 55455,undefined
[8] USA,undefined
[9] Harvard Medical School,undefined
[10] 240 Longwood Avenue,undefined
[11] Boston,undefined
[12] Massachusetts 02115,undefined
[13] USA,undefined
来源：
Nature | 2008年 / 452卷
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摘要：
The cellular cytosine deaminase APOBEC3G inhibits replication of HIV lacking the viral protein Vif; here the NMR structure of a mutant form of the catalytic domain of APOBEC3G is reported, and a model for the APOBEC–DNA interaction is proposed.
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页码：116 / 119
页数：3
相关论文
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