Synthesis, characterization and anticancer activity of 3-aminopyrazine-2-carboxylic acid transition metal complexes

被引：0
|
作者：
Issam M. Gabr
Hala A. El-Asmy
Mohamed S. Emmam
Sahar I. Mostafa
机构：
[1] Mansoura University,Chemistry Department, Faculty of Science
来源：
Transition Metal Chemistry | 2009年 / 34卷
关键词：
PPh3; Conductivity Data; Ehrlich Ascites Tumour Cell; RhCl3; Mean Survival Time;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Synthetic procedures are described that allow access to the new complexes cis-[Mo2O5(apc)2], cis-[WO2(apc)2], trans-[UO2(apc)2], [Ru(apc)2(H2O)2], [Ru(PPh3)2(apc)2], [Rh(apc)3], [Rh(PPh3)2(apc)2]ClO4, [M(apc)2], [M(PPh3)2(apc)]Cl, [M(bpy)(apc)]Cl (M(II) = Pd, Pt), [Pd(bpy)(apc)Cl], [Ag(apc)(H2O)2] and [Ir(bpy)(Hapc)2]Cl3, where Hapc, is 3-aminopyrazine-2-carboxylic acid. These complexes were characterized by physico-chemical and spectroscopic techniques. Both Hapc and several of its complexes display significant anticancer activity against Ehrlich ascites tumour cells (EAC) in albino mice.
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页码：409 / 418
页数：9
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