WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?

被引：0
作者：
Nicolas Gillet
Alexandre Carpentier
Pierre-Yves Barez
Luc Willems
机构：
[1] University of Liège,Molecular and Cellular Epigenetics, GIGA
[2] University of Liège,Molecular biology, GxABT
来源：
Retrovirology | / 9卷
关键词：
HTLV-1; Tax; HBZ; p53; Wip1; PPM1D; MDM2; DNA damage response; Genomic stress; ATM; Chk2;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1 (HTLV-1) Tax transformation. However, p53 genomic mutations are late and rather infrequent events in HTLV-1 induced Adult T cell leukemia (ATL). The paper by Zane et al. shows that a mediator of p53 activity, Wild-type p53-induced phosphatase 1 (Wip1), contributes to Tax-induced oncogenesis in a mouse model. Wip1 may therefore be a novel target for therapeutic approaches.
引用
收藏
相关论文
共 23 条
[21]   Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site [J].
Takeshi Suzuki ;
Masami Uchida-Toita ;
Mitsuaki Yoshida .
Oncogene, 1999, 18 :4137-4143
[22]   Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site [J].
Suzuki, T ;
Uchida-Toita, M ;
Yoshida, M .
ONCOGENE, 1999, 18 (28) :4137-4143
[23]   Clinical features and treatment outcomes of opportunistic infections among human T-Iymphotrophic virus type 1 (HTLV-1) carriers and patients with adult T-cell leukemia-lymphoma (ATL) at a single institution from 2006 to 2016 [J].
Kawano, Noriaki ;
Nagahiro, Yuri ;
Yoshida, Shuro ;
Tahara, Yoshihiro ;
Himeji, Daisuke ;
Kuriyama, Takuro ;
Tochigi, Taro ;
Nakaike, Takashi ;
Shimokawa, Tomonori ;
Yamashita, Kiyoshi ;
Ochiai, Hidenobu ;
Marutsuka, Kouske ;
Mashiba, Koichi ;
Shimoda, Kazuya ;
Teshima, Takanori ;
Kikuchi, Ikuo .
JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2019, 59 (04) :156-167
123