Molecular genetic analysis of Isoniazid-resistant strains of Mycobacterium tuberculosis circulating in the Saratov region

被引：0
|
作者：
T. Yu. Salina
T. I. Morozova
机构：
[1] Saratov Regional Clinical Antituberculosis Dispensary,
[2] Saratov Razumovsky State Medical University,undefined
来源：
Molecular Genetics, Microbiology and Virology | 2013年 / 28卷
关键词：
tuberculosis; drug resistance; Isoniazid; gene mutations;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The distribution and mutation spectrum of the katG, inhA, and ahpC genes encoding Isoniazid resistance have been studied in 257 patients with active lung tuberculosis in Saratov oblast. The tests were performed using biological microchips from TB-Biochip MDR pharmacological kits (Russia). The incidence rate of Isoniazid-resistant M. tuberculosis strains was found to be 55.7%. Isoniazid-resistant strains demonstrated a high rate (26.9%) of combined mutations in two and three genes simultaneously and predominance in gene katG Ser315 → Thr1 (91.1%) inducing high resistance to Isoniazid. The sensitivity and specificity of the TB-Biochip MDR test system were 88.2 and 91.3%, respectively. The results of this work show additional measures must be taken to reduce the incidence of Isoniazid-resistant strains.
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页码：115 / 118
页数：3
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