Androgen Action in Prostate Cancer

被引：34
作者：
Basu S. [1 ]
Tindall D.J. [2 ]
机构：
[1] Department of Pathology, Ohio State University, Columbus
[2] Departments of Urology and Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester
来源：
Hormones and Cancer | 2010年 / 1卷 / 5期
关键词：
Androgen; Androgen ablation therapy; Prostate;
D O I：
10.1007/s12672-010-0044-4
中图分类号：
学科分类号：
摘要：
Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. Androgens act by binding to the androgen receptor (AR), a nuclear receptor transcription factor present in the prostate tissues. Most prostate tumors also retain their androgen dependence; therefore, androgen ablation is usually the preferred initial therapeutic approach for the treatment of advanced prostate cancer patients. This review summarizes the current information regarding the role of androgens in prostate cancer. © 2010 Springer Science+Business Media, LLC.
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收藏
页码：223 / 228
页数：5
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