Influence of ethacrynic acid on the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock seizure model

被引：0

作者：

Łukawski K. ^{[1
]}

Świderska G. ^{[1
]}

Łuszczki J.J. ^{[1
,2
]}

Czuczwar S.J. ^{[1
,2
]}

机构：

[1] Department of Physiopathology, Institute of Agricultural Medicine, PL 20-090 Lublin

[2] Department of Pathophysiology, Medical University of Lublin, PL 20-090 Lublin

来源：

Pharmacological Reports | 2010年 / 62卷 / 5期

关键词：

Antiepileptic drugs; Ethacrynic acid; Maximal electroshock seizure test; Pharmacodynamic interaction;

D O I：

10.1016/S1734-1140(10)70341-8

中图分类号：

学科分类号：

摘要：

The aim of this study was to determine whether ethacrynic acid (EA), a loop diuretic with anticonvulsant activity, would affect the protective action of the conventional antiepileptics (AEDs) carbamazepine (CBZ), phenytoin (PHT), valproate (VPA) and phenobarbital (PB) in the mouse maximal electroshock seizure (MES) model. The effects of acute and chronic treatment with EAon these AEDs were examined. At a single dose of 100 mg/kg ip, EA enhanced the antielectroshock activity of VPA, decreasing its ED50 value from 225.6 to 146.6 mg/kg (p < 0.05), but enhancement was not observed following continuous administration of EA (12.5 mg/kg) for seven days. Combined treatment of EA with other AEDs had no effect on their ED50 values. The observed interaction between EA and VPA was pharmacodynamic in nature as EA did not alter free plasma (non-protein-bound) and total brain concentrations of VPA. Taking into consideration the clinical use of both drugs, this interaction between EA and VPA can be important for patients receiving these drugs. Copyright © 2010 by Institute of Pharmacology Polish Academy of Sciences.

引用

页码：808 / 813

页数：5

共 31 条

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