CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

被引：0
作者：
Xuefang Ren
Kozaburo Akiyoshi
Arthur A. Vandenbark
Patricia D. Hurn
Halina Offner
机构：
[1] Portland Veterans Affairs Medical Center,Neuroimmunology Research, R&D
[2] Oregon Health & Science University,31
[3] Oregon Health & Science University,Department of Anesthesiology and Perioperative Medicine
[4] Oregon Health & Science University,Department of Neurology
来源：
Metabolic Brain Disease | 2011年 / 26卷
关键词：
Cerebral ischemia; T lymphocyte; T regulatory cells; Middle cerebral artery occlusion; Stroke;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25+Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
引用
收藏
页码：87 / 90
页数：3
相关论文
共 46 条
  • [1] Dirnagl U(2007)Stroke induced immunodepression, experimental evidence and clinical relevance Stroke 38 770-773
  • [2] Klehmet J(2007)Regulatory T cells prevent catastrophic autoimmunology throughout the lifespan of mice Nat Immunol 8 191-197
  • [3] Braun J(2009)Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke Nat Med 15 192-199
  • [4] Harms H(2006)Experimental stroke induces massive rapid activation of the peripheral immune system J Cereb Blood Flow Metab 26 654-665
  • [5] Meisel C(2006)Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages J Immunol 176 6523-6531
  • [6] Ziemssen T(2007)Experimental treatments for acute ischaemic stroke Lancet 369 331-341
  • [7] Prass K(2006)Foxp + CD25 + CD4+ natural T cells in dominant self-tolerance and autoimmune disease Immunol Rev 212 8-27
  • [8] Meisel A(undefined)undefined undefined undefined undefined-undefined
  • [9] Kim JM(undefined)undefined undefined undefined undefined-undefined
  • [10] Rasmussen JP(undefined)undefined undefined undefined undefined-undefined
12345