High-frequency repetitive transcranial magnetic stimulation (rTMS) protects against ischemic stroke by inhibiting M1 microglia polarization through let-7b-5p/HMGA2/NF-κB signaling pathway

被引:0
作者
Ye Hong
Jinfeng Lyu
Lin Zhu
Xixi Wang
Mengna Peng
Xiangliang Chen
Qiwen Deng
Jie Gao
Zhenhua Yuan
Di Wang
Gelin Xu
Mengyi Xu
机构
[1] Nanjing Medical University,Department of Neurology, Nanjing First Hospital
[2] Medical School of Nanjing University,Department of Neurology, Jinling Hospital
来源
BMC Neuroscience | / 23卷
关键词
Ischemic stroke; Microglia polarization; rTMS; Let-7b-5p; HMGA2; NF-κB;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 220 条
  • [1] Iadecola C(2011)The immunology of stroke: from mechanisms to translation Nat Med 17 796-808
  • [2] Anrather J(2005)Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice Exp Neurol 196 290-297
  • [3] Schilling M(2017)The biphasic function of microglia in ischemic stroke Prog Neurobiol 157 247-272
  • [4] Besselmann M(2016)Functional polarization of neuroglia: implications in neuroinflammation and neurological disorders Biochem Pharmacol 103 1-16
  • [5] Müller M(2012)Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia Stroke 43 3063-3070
  • [6] Strecker JK(2018)The use of repetitive transcranial magnetic stimulation for stroke rehabilitation: a systematic review J Stroke Cerebrovasc Dis 27 1-31
  • [7] Ringelstein EB(2018)Effects of high- and low-frequency repetitive transcranial magnetic stimulation on motor recovery in early stroke patients. Evidence from a randomized controlled trial with clinical, neurophysiological and functional imaging assessments Neuroimage Clin 21 101620-91
  • [8] Kiefer R(2015)Possible mechanisms underlying the therapeutic effects of transcranial magnetic stimulation Front Hum Neurosci 9 303-299
  • [9] Ma Y(2016)How does transcranial magnetic stimulation influence glial cells in the central nervous system? Front Neural Circuits 10 26-103
  • [10] Wang J(2013)Response of hippocampal neurons and glial cells to alternating magnetic field in gerbils submitted to global cerebral ischemia Neurotox Res 23 79-194