Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

被引:0
作者
Sammy Bedoui
Paul G Whitney
Jason Waithman
Liv Eidsmo
Linda Wakim
Irina Caminschi
Rhys S Allan
Magdalena Wojtasiak
Ken Shortman
Francis R Carbone
Andrew G Brooks
William R Heath
机构
[1] The University of Melbourne,The Department of Microbiology and Immunology
[2] The Walter and Eliza Hall Institute of Medical Research,undefined
来源
Nature Immunology | 2009年 / 10卷
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摘要
The functions of individual dendritic cell subsets in the skin are unclear. Heath and colleagues now show that langerin-positive CD103+ dermal dendritic cells are the main migratory subtype able to cross-present antigen.
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页码:488 / 495
页数:7
相关论文
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[1]  
Steinman RM(2007)Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system Nat. Med. 13 1155-1159
[2]  
Villadangos JA(2005)Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigm Semin. Immunol. 17 262-272
[3]  
Heath WR(2002)Mouse and human dendritic cell subtypes Nat. Rev. Immunol. 2 151-161
[4]  
Shortman K(2007)Steady-state and inflammatory dendritic-cell development Nat. Rev. Immunol. 7 19-30
[5]  
Liu Y(2004)Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens Immunol. Rev. 199 9-26
[6]  
Shortman K(2008)Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes J. Exp. Med. 205 2839-2850
[7]  
Naik SH(2008)Dendritic cell-induced memory T cell activation in nonlymphoid tissues Science 319 198-202
[8]  
Heath WR(2003)Distinct dendritic cell populations sequentially present antigen to CD4 Immunity 19 47-57
[9]  
Jakubzick C(2006) T cells and stimulate different aspects of cell-mediated immunity Immunity 25 153-162
[10]  
Wakim LM(1999)Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming Nat. Med. 5 919-923