Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

被引:0
|
作者
Markus W. Löffler
Christopher Mohr
Leon Bichmann
Lena Katharina Freudenmann
Mathias Walzer
Christopher M. Schroeder
Nico Trautwein
Franz J. Hilke
Raphael S. Zinser
Lena Mühlenbruch
Daniel J. Kowalewski
Heiko Schuster
Marc Sturm
Jakob Matthes
Olaf Riess
Stefan Czemmel
Sven Nahnsen
Ingmar Königsrainer
Karolin Thiel
Silvio Nadalin
Stefan Beckert
Hans Bösmüller
Falko Fend
Ana Velic
Boris Maček
Sebastian P. Haen
Luigi Buonaguro
Oliver Kohlbacher
Stefan Stevanović
Alfred Königsrainer
Hans-Georg Rammensee
机构
[1] University Hospital Tübingen,Department of General, Visceral and Transplant Surgery
[2] University of Tübingen,Interfaculty Institute for Cell Biology, Department of Immunology
[3] German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Partner Site Tübingen,Department of Clinical Pharmacology
[4] University Hospital Tübingen,Institute for Translational Bioinformatics
[5] University Hospital Tübingen,Quantitative Biology Center (QBiC)
[6] University of Tübingen,Center for Bioinformatics
[7] University of Tübingen,Department of Computer Science
[8] Applied Bioinformatics,Institute of Medical Genetics and Applied Genomics
[9] Present address: European Molecular Biology Laboratory,NGS Competence Center Tübingen (NCCT)
[10] European Bioinformatics Institute (EMBL-EBI),Present address: Department of General and Visceral Surgery
[11] University Hospital Tübingen,Institute of Pathology and Neuropathology
[12] Present address: Immatics Biotechnologies GmbH,Interfaculty Institute for Cell Biology, Proteome Center Tübingen (PCT)
[13] University of Tübingen,Internal Medicine, Department for Oncology, Hematology, Immunology, Rheumatology and Pulmonology
[14] Schwarzwald-Baar Hospital,Cancer Immunoregulation Unit
[15] University Hospital Tübingen,undefined
[16] University of Tübingen,undefined
[17] University of Tübingen,undefined
[18] Istituto Nazionale per lo Studio e la Cura dei Tumori,undefined
[19] “Fondazione Pascale” – IRCCS,undefined
[20] Max Planck Institute for Developmental Biology,undefined
[21] Biomolecular Interactions,undefined
来源
Genome Medicine | / 11卷
关键词
Hepatocellular carcinoma; HLA; HLA ligandomics; Immunoinformatics; Immunotherapy; Liver cancer; Mass spectrometry; Multi-omics; Neoantigen; Next-generation sequencing; Peptide prediction; Personalized medicine;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Multi-Omics and Management of Follicular Carcinoma of the Thyroid
    Luvhengo, Thifhelimbilu Emmanuel
    Bombil, Ifongo
    Mokhtari, Arian
    Moeng, Maeyane Stephens
    Demetriou, Demetra
    Sanders, Claire
    Dlamini, Zodwa
    BIOMEDICINES, 2023, 11 (04)
  • [32] SAA1 identified as a potential prediction biomarker for metastasis of hepatocellular carcinoma via multi-omics approaches
    Li, Gang
    Shen, Qingrong
    Xu, Haotian
    Zhou, Ying
    Li, Cuiping
    Li, Yasi
    He, Min
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [33] Title: Multi-Omics and Immune Landscape of Proliferative LncRNA Signatures: Implications for Risk Stratification and Immunotherapy in Hepatocellular Carcinoma
    Liu, Chi
    Gao, Jie
    Yang, Dongjing
    Yu, Qiwen
    Zhang, Shuijun
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [34] Tumor Prognostic Risk Model Related to Monocytes/Macrophages in Hepatocellular Carcinoma Based on Machine Learning and Multi-Omics
    Wan, Xinliang
    Zou, Yongchun
    Zhou, Qichun
    Tang, Qing
    Zhu, Gangxing
    Jia, Luyu
    Yu, Xiaoyan
    Mo, Handan
    Yang, Xiaobing
    Wang, Sumei
    BIOLOGICAL PROCEDURES ONLINE, 2025, 27 (01)
  • [35] Multi-omics analysis revealed the novel role of NQO1 in microenvironment, prognosis and immunotherapy of hepatocellular carcinoma
    Tang, Ya
    Hu, Haihong
    Chen, Siyuan
    Hao, Bo
    Xu, Xuefeng
    Zhu, Hongxia
    Zhan, Wendi
    Zhang, Taolan
    Hu, Hongjuan
    Chen, Guodong
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [36] Multi-omics analysis of pyroptosis regulation patterns and characterization of tumor microenvironment in patients with hepatocellular carcinoma
    Shang, Bingbing
    Wang, Ruohan
    Qiao, Haiyan
    Zhao, Xixi
    Wang, Liang
    Sui, Shaoguang
    PEERJ, 2023, 11
  • [37] Identification of Tumor Mutation Burden and Immune Infiltrates in Hepatocellular Carcinoma Based on Multi-Omics Analysis
    Yin, Lu
    Zhou, Liuzhi
    Xu, Rujun
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 7
  • [38] Integrated Multi-Omics Data Analysis Reveals Associations Between Glycosylation and Stemness in Hepatocellular Carcinoma
    Liu, Peiyan
    Zhou, Qi
    Li, Jia
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [39] Advanced mass spectrometry-based multi-omics technologies for exploring the pathogenesis of hepatocellular carcinoma
    Nie, Wenna
    Yan, Leyu
    Lee, Yie H.
    Guha, Chandan
    Kurland, Irwin J.
    Lu, Haitao
    MASS SPECTROMETRY REVIEWS, 2016, 35 (03) : 331 - 349
  • [40] SLC7A11, a disulfidptosis-related gene, correlates with multi-omics prognostic analysis in hepatocellular carcinoma
    Li, Shizhe
    Wang, Xiaotong
    Xiao, Junbo
    Yi, Jun
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2025, 30 (01) : 161