Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

被引：0

作者：

Markus W. Löffler

Christopher Mohr

Leon Bichmann

Lena Katharina Freudenmann

Mathias Walzer

Christopher M. Schroeder

Nico Trautwein

Franz J. Hilke

Raphael S. Zinser

Lena Mühlenbruch

Daniel J. Kowalewski

Heiko Schuster

Marc Sturm

Jakob Matthes

Olaf Riess

Stefan Czemmel

Sven Nahnsen

Ingmar Königsrainer

Karolin Thiel

Silvio Nadalin

Stefan Beckert

Hans Bösmüller

Falko Fend

Ana Velic

Boris Maček

Sebastian P. Haen

Luigi Buonaguro

Oliver Kohlbacher

Stefan Stevanović

Alfred Königsrainer

Hans-Georg Rammensee

机构：

[1] University Hospital Tübingen,Department of General, Visceral and Transplant Surgery

[2] University of Tübingen,Interfaculty Institute for Cell Biology, Department of Immunology

[3] German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Partner Site Tübingen,Department of Clinical Pharmacology

[4] University Hospital Tübingen,Institute for Translational Bioinformatics

[5] University Hospital Tübingen,Quantitative Biology Center (QBiC)

[6] University of Tübingen,Center for Bioinformatics

[7] University of Tübingen,Department of Computer Science

[8] Applied Bioinformatics,Institute of Medical Genetics and Applied Genomics

[9] Present address: European Molecular Biology Laboratory,NGS Competence Center Tübingen (NCCT)

[10] European Bioinformatics Institute (EMBL-EBI),Present address: Department of General and Visceral Surgery

[11] University Hospital Tübingen,Institute of Pathology and Neuropathology

[12] Present address: Immatics Biotechnologies GmbH,Interfaculty Institute for Cell Biology, Proteome Center Tübingen (PCT)

[13] University of Tübingen,Internal Medicine, Department for Oncology, Hematology, Immunology, Rheumatology and Pulmonology

[14] Schwarzwald-Baar Hospital,Cancer Immunoregulation Unit

[15] University Hospital Tübingen,undefined

[16] University of Tübingen,undefined

[17] University of Tübingen,undefined

[18] Istituto Nazionale per lo Studio e la Cura dei Tumori,undefined

[19] “Fondazione Pascale” – IRCCS,undefined

[20] Max Planck Institute for Developmental Biology,undefined

[21] Biomolecular Interactions,undefined

来源：

Genome Medicine | / 11卷

关键词：

Hepatocellular carcinoma; HLA; HLA ligandomics; Immunoinformatics; Immunotherapy; Liver cancer; Mass spectrometry; Multi-omics; Neoantigen; Next-generation sequencing; Peptide prediction; Personalized medicine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 469 条

[1]

Torre LA(2015)Global cancer statistics, 2012 CA Cancer J Clin 65 87-108

[2]

Bray F(2011)Immunotherapeutic modulation of the suppressive liver and tumor microenvironments Int Immunopharmacol 11 879-889

[3]

Siegel RL(2007)Spontaneous and vaccine induced AFP-specific T cell phenotypes in subjects with AFP-positive hepatocellular cancer Cancer Immunol Immunother 56 1931-1943

[4]

Ferlay J(2017)The prognostic value of tumor-infiltrating lymphocytes in hepatocellular carcinoma: a systematic review and meta-analysis Sci Rep 7 7525-253

[5]

Lortet-Tieulent J(2006)Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation J Hepatol 45 246-34

[6]

Jemal A(2015)Combined Nivolumab and Ipilimumab or monotherapy in untreated melanoma N Engl J Med 373 23-1894

[7]

Chan T(2015)Pooled analysis of long-term survival data from phase II and phase III trials of Ipilimumab in Unresectable or metastatic melanoma J Clin Oncol 33 1889-74

[8]

Wiltrout RH(2015)Neoantigens in cancer immunotherapy Science. 348 69-1217

[9]

Weiss JM(2013)HLA ligandome tumor antigen discovery for personalized vaccine approach Expert Rev Vaccines 12 1211-1100

[10]

Butterfield LH(2013)Immunotherapy at large: the road to personalized cancer vaccines Nat Med 19 1098-2199

← 1 2 3 4 5 6 7 8 9 10 →