Glucocorticoid receptor changes are associated with age in the hippocampus of Zucker diabetic fatty rats

被引:1
|
作者
Yi S.S. [1 ]
Seong J.K. [2 ]
机构
[1] Department of Biomedical Laboratory Science, College of Biomedical Sciences, Soonchunhyang University, Asan
[2] Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul
关键词
Age; Glucocorticoid receptor; Hippocampus; Type; 2; diabetes; Zucker diabetic fatty rat;
D O I
10.1007/s13530-013-0153-x
中图分类号
学科分类号
摘要
Diabetes is a metabolic disorder that is associated with dysfunction of a number of systems within the body and an excess of glucocorticoid is one of the characteristics seen in patients with type 2 diabetes. In the present study, we investigated the glucocorticoid receptor (GR) immunoreactivity and its protein levels in the hippocampus of 4-(pre-diabetic), 12-, 20- and 30-week-old Zucker diabetic fatty (fa/fa, ZDF) rats and Zucker lean control (fa/+, +/+, ZLC) rats. Progressive diabetic condition gradually develops from 7 weeks of age and is complete at 12 weeks of age in ZDF rats, thereafter the chronic diabetic condition is maintained. GR immunoreactivity was mainly detected in the hippocampal CA1 and dentate gyrus, and GR protein levels were exponentially increased along with the age. The GR immunoreactivity and protein levels were markedly increased in ZDF rats than in age-matched ZLC rats except in the 4-weekold group. GR protein levels in the hippocampus of the 20- and 30-week ZDF rats were significantly increased compared with the 4- and 12-week-old ZDF rats. The present study suggests that GR immunoreactivity and its protein level in type 2 diabetic conditions are associated with age, and the GR expression in the hippocampus may be significantly increased in progressive chronic type 2 diabetic condition. © 2013 Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.
引用
收藏
页码:34 / 40
页数:6
相关论文
共 50 条
  • [41] Vasopeptidase inhibition prevents nephropathy in Zucker diabetic fatty rats
    Schäfer, S
    Linz, W
    Bube, A
    Gerl, M
    Huber, J
    Kürzel, GU
    Bleich, M
    Schmidts, HL
    Busch, AE
    Rütten, H
    CARDIOVASCULAR RESEARCH, 2003, 60 (02) : 447 - 454
  • [42] Sulfur amino acid metabolism in Zucker diabetic fatty rats
    Kwak, Hui Chan
    Kim, Young-Mi
    Oh, Soo Jin
    Kim, Sang Kyum
    BIOCHEMICAL PHARMACOLOGY, 2015, 96 (03) : 256 - 266
  • [43] Effect of Exercise on Pancreatic Islets in Zucker Diabetic Fatty Rats
    Rawal, Sonia
    Huang, Han-Hung
    Novikova, Lesya
    Hamedi, Tyler
    Smirnova, Irina V.
    Stehno-Bittel, Lisa
    JOURNAL OF DIABETES & METABOLISM, 2013, 4
  • [44] PPARα Activation with Fenofibrate Attenuates Diabetic Nephropathy in Zucker Diabetic Fatty Rats
    Li, Lingyun
    Zhao, Xueying
    FASEB JOURNAL, 2008, 22
  • [45] Histologic Characterization of Retina Neuroglia Modifications in Diabetic Zucker Diabetic Fatty Rats
    Fernandez-Bueno, Ivan
    Jones, Robert
    Soriano-Romani, Laura
    Lopez-Garcia, Antonio
    Galvin, Orla
    Cheetham, Sharon
    Diebold, Yolanda
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (11) : 4925 - 4933
  • [46] Histological Evaluation of Diabetic Neurodegeneration in the Retina of Zucker Diabetic Fatty (ZDF) Rats
    Szabo, Klaudia
    Enzsoly, Anna
    Dekany, Bulcsu
    Szabo, Arnold
    Hajdu, Rozina I.
    Radovits, Tamas
    Matyas, Csaba
    Olah, Attila
    Laurik, Lenke K.
    Somfai, Gabor M.
    Merkely, Bela
    Szel, Agoston
    Lukats, Akos
    SCIENTIFIC REPORTS, 2017, 7
  • [47] Histological Evaluation of Diabetic Neurodegeneration in the Retina of Zucker Diabetic Fatty (ZDF) Rats
    Klaudia Szabó
    Anna Énzsöly
    Bulcsú Dékány
    Arnold Szabó
    Rozina I. Hajdú
    Tamás Radovits
    Csaba Mátyás
    Attila Oláh
    Lenke K. Laurik
    Gábor M. Somfai
    Béla Merkely
    Ágoston Szél
    Ákos Lukáts
    Scientific Reports, 7
  • [48] Evaluation of Metanx on diabetic peripheral neuropathy in Zucker diabetic fatty (ZDF) rats
    Maksimchyk, Yury
    Watcho, Pierre
    Shevalye, Hanna
    Obrosova, Irina G.
    FASEB JOURNAL, 2011, 25
  • [49] Metabolic profile of the hippocampus of Zucker Diabetic Fatty rats assessed by in vivo 1H magnetic resonance spectroscopy
    van der Graaf, M
    Janssen, SWJ
    van Asten, JJA
    Hermus, ARMM
    Sweep, CGJ
    Pikkemaat, JA
    Martens, GJM
    Heerschap, A
    NMR IN BIOMEDICINE, 2004, 17 (06) : 405 - 410
  • [50] Age-dependent development of metabolic derangement and effects of intervention with pioglitazone in Zucker diabetic fatty rats
    Szoecs, Zsuzsanna
    Brunmair, Barbara
    Stadlbauer, Karin
    Nowotny, Peter
    Bauer, Leonhardt
    Luger, Anton
    Fuernsinn, Clemens
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 326 (01): : 323 - 329