γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate

[1] Aghi M(1999)Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and J Natl Cancer Inst 91 1233-1241

[2] Kramm CM(1981)Metabolic modification by insulin enhances methotrexate cytotoxicity in MCF-7 human breast cancer cells Eur J Cancer Clin Oncol 17 1223-1228

[3] Breakefield XO(2000)Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates Int J Cancer 87 771-778

[4] Alabaster O(2010)Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged>or =60 y in the United States Am J Clin Nutr 92 383-389

[5] Vonderhaar BK(2006)Homocysteine lowering and cardiovascular events after acute myocardial infarction New Engl J Med 354 1578-1588

[6] Shafie SM(2000)Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status Br J Cancer 82 913-923

[7] Backus HH(2005)A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation Br J Cancer 93 639-646

[8] Pinedo HM(1994)Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer J Clin Oncol 12 14-20

[9] Wouters D(2004)A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells Pharmacogenetics 14 557-567

[10] Padron JM(1997)Relevance of tumoral folylpolyglutamate synthetase and reduced folates for optimal 5-fluorouracil efficacy: experimental data Eur J Cancer 33 950-959

[1] Aghi M(1999)Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and J Natl Cancer Inst 91 1233-1241

[2] Kramm CM(1981)Metabolic modification by insulin enhances methotrexate cytotoxicity in MCF-7 human breast cancer cells Eur J Cancer Clin Oncol 17 1223-1228

[3] Breakefield XO(2000)Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates Int J Cancer 87 771-778

[4] Alabaster O(2010)Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged>or =60 y in the United States Am J Clin Nutr 92 383-389

[5] Vonderhaar BK(2006)Homocysteine lowering and cardiovascular events after acute myocardial infarction New Engl J Med 354 1578-1588

[6] Shafie SM(2000)Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status Br J Cancer 82 913-923

[7] Backus HH(2005)A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation Br J Cancer 93 639-646

[8] Pinedo HM(1994)Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer J Clin Oncol 12 14-20

[9] Wouters D(2004)A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells Pharmacogenetics 14 557-567

[10] Padron JM(1997)Relevance of tumoral folylpolyglutamate synthetase and reduced folates for optimal 5-fluorouracil efficacy: experimental data Eur J Cancer 33 950-959