Impact of left atrial appendage location on risk of thrombus formation in patients with atrial fibrillation

被引：0
作者：
Runxin Fang
Yang Li
Yanjuan Zhang
Qiang Chen
Quanjun Liu
Zhiyong Li
机构：
[1] Southeast University,School of Biological Science and Medical Engineering
[2] Southeast University,Zhongda Hospital
[3] Nanjing Medical University,First Affiliated Hospital
[4] Queensland University of Technology (QUT),School of Mechanical, Medical and Process Engineering
来源：
Biomechanics and Modeling in Mechanobiology | 2021年 / 20卷
关键词：
Atrial fibrillation; Left atrial appendage; Hemodynamics; Thrombus formation; Fluid–structure interaction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Most strokes in patients with atrial fibrillation (AF) are thought to arise from thrombus formation in the left atrial appendage (LAA). Assessing the hemodynamics in LAA and left atrium (LA) may provide some insights in the evaluation of the risk of thrombus formation. This study aims to find out the impact of different LAA locations with respect of LA on the risk of thrombus formation within LAA in patients with AF. Three different LAA locations at LA were modeled and a fully coupled fluid–structure interaction analysis was performed. A discrete phase method was used for particle residence analysis to evaluate risk of the thrombus formation. The results showed that LAA positions on the LA affected the LAA flow velocity distribution, passive contraction ability, and particle residence. In particular, the left pulmonary veins (PVs) had a greater influence on the LAA hemodynamics than the right PVs. The LAA had the lowest contractibility when it was located between left superior and left inferior PVs, and in this case, a larger number of particles were resided, which indicated a higher risk of thrombus formation. The present work provides a quantitative way to evaluate the risk of thrombus formation within LAA in patients with AF.
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页码：1431 / 1443
页数：12
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