Sirtuins: Role in the Regulation of Oxidative Stress and the Pathogenesis of Neurodegenerative Diseases

被引：0
作者：
Pukhalskaia A.E. [1 ]
Diatlova A.S. [1 ]
Linkova N.S. [1 ,2 ,3 ]
Kvetnoy I.M. [1 ,4 ,5 ]
机构：
[1] Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg
[2] Department of Therapy, Geriatrics, and Antiaging Medicine, Postgraduate Educational Academy, Federal Medical Biological Agency, Moscow
[3] Department of Medical and Biological Disciplines, Belgorod National Research State University, Belgorod
[4] Department of Pathology, St. Petersburg State University, St. Petersburg
[5] Center for Molecular Biomedicine, St. Petersburg Research Institute of Phthisiopulmonology, Russian Federation Ministry of Health, St. Petersburg
来源：
Neuroscience and Behavioral Physiology | 2022年 / 52卷 / 1期
关键词：
Alzheimer’s disease; oxidative stress; Parkinson’s disease; Sirtuins;
D O I：
10.1007/s11055-022-01217-3
中图分类号：
学科分类号：
摘要：
Sirtuins (SIRTs) are a family of histone deacetylases which epigenetically regulate major cell functions. This review analyzes the role of SIRTs in controlling oxidation-reduction reactions in cells in stress. Oxidative stress and mitochondrial dysfunction are among the causes of the development of neurodegenerative pathologies – Alzheimer’s disease (AD) and Parkinson’s disease (PD). SIRTs supporting the antioxidant defense of neurons may play an important role in the pathogenesis of AD and PD. This article summarizes the molecular mechanisms of the neuroprotective properties of SIRT1, 2, 3, and 6 in AD and SIRT1 and 3 in PD. The roles of other proteins of the SIRT family in the pathogenesis of neurodegenerative diseases requires further study. SIRTs may have potential as diagnostic markers and treatment targets in AD and PD. © 2022, Springer Science+Business Media, LLC, part of Springer Nature.
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页码：164 / 174
页数：10
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