The Use of High-Dose insulin-glucose euglycemia in beta-blocker overdose: A case report

被引：32

作者：

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Hacket L.P. ^{[2
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Isbister G.K. ^{[1
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机构：

[1] Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW

[2] Department of Clinical Pharmacology and Toxicology, Path West Laboratory Medicine WA, Perth, WA

[3] Discipline of Clinical Pharmacology, Faculty of Health, University of Newcastle, Newcastle, NSW

[4] Tropical Toxicology Unit, Menzies School of Health Research, Charles Darwin University, Darwin

来源：

Journal of Medical Toxicology | 2009年 / 5卷 / 3期

基金：

英国医学研究理事会;

关键词：

Beta-blocker toxicity; Euglycemia; High-dose insulin;

D O I：

10.1007/BF03161225

中图分类号：

学科分类号：

摘要：

The management of life-threatening beta-blocker toxicity and its associated low cardiac output state is clinically challenging. Previous case reports and case series describe the use of hyperinsulinemia/euglycemia therapy in mono-ingestions of calcium channel blockers and mixed ingestions, including calcium channel and beta-blockers. In this case report we describe the use of high-dose insulin (10 IU/kg per hour) in a case of massive metoprolol ingestion (5 g) in which hypotension was unresponsive to conventional therapies. Although the metoprolol concentrations measured in plasma were approximately 100-200 times therapeutic concentrations, the pharmacokinetics appeared to be similar to therapeutic metoprolol dosing.

引用

页码：139 / 143

页数：4

共 12 条

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