Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted-piperazine-1-yl)propyl]pyridazin-3(2H)-one derivatives as anticancer agents

被引：0
作者：
M. S. R. Murty
B. Ramalingeswara Rao
Kesur R. Ram
J. S. Yadav
Jayesh Antony
Ruby John Anto
机构：
[1] Discovery Laboratory,Organic Chemistry Division
[2] Indian Institute of Chemical Technology,I
[3] Rajiv Gandhi Centre for Biotechnology,Integrated Cancer Research Program, Division of Cancer Research
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Pyridazinones; Cyclic amines; Hydrazide; Anticancer activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of new 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substituted piperazine-1-yl)propyl] pyridazin-3(2H)-one derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H NMR, and mass spectral data. All the compounds were evaluated for their cytotoxicity toward five human cancer cell lines of different origins viz; HeLa (Cervical), SKBR3 (Breast), HCT116 (Colon), A375 (Skin) & H1299 (Lung) at different concentrations and the IC50 values were determined. HCT116 and HeLa are the most sensitive against the compounds studied. One of them displayed moderate cytotoxicity against SKBR3. Majority of the compounds exhibited good to moderate activity.
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页码：3161 / 3169
页数：8
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