Synthesis, Antihelminthic and Insecticidal Activity of 2-[3-Methyl-6-Methoxy-7-(n-Propoxy)-3,4-Dihydroisoquinolin-1]Ethanoic Acid Amides

被引：0
|
作者：
O. V. Surikova
A. G. Mikhailovskii
B. Ya. Syropyatov
A. S. Yusov
Yu. D. Khudyakova
机构：
[1] Perm State Pharmaceutical Academy,
来源：
Pharmaceutical Chemistry Journal | 2017年 / 51卷
关键词：
cyclocondensation of O-; -propylated eugenol with cyanoacetamides; 2-[3-methyl-6-methoxy-7-(; -propoxy)-3,4-dihydroisoquinolin-1]ethanoic acid amide hydrochlorides; antihelminthic activity greater than that of Pyrantel; insecticidal activity comparable with that of diazinon and pirimiphos;
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学科分类号：
摘要：
Cyclocondensation of O-n-propylated eugenol with cyanoacetamides was used to synthesize 2-[3-methyl-6-methoxy-7-(n-propoxy)-3,4-dihydroisoquinolin-1]ethanoic acid amides. The hydrochlorides of these compounds were tested for antihelminthic and insecticidal activity. The most active compounds were amides containing a cyclic amine fragment (pyrrolidine, piperidine, morpholine), which had greater activity than Pyrantel. Compounds without substituents at the amide nitrogen and the N-ethylamide had insecticidal activity at the levels of diazinon and pirimiphos.
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页码：22 / 25
页数：3
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