Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors

[1] Ackland SP(1999)Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs Drug Resist Update 2 205-214

[2] Peters GJ(2006)Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton Mol Cancer Ther 5 2348-2357

[3] Bijman MN(2010)Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells Biochem Pharmacol 80 786-792

[4] van Nieuw Amerongen GP(2010)Increased migration by stimulation of thymidine phosphorylase in endothelial cells of different origin Nucleosides Nucleotides Nucleic Acids 29 482-487

[5] Laurens N(2009)Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule ‘crystallization chaperone’ 5′-O-tritylinosine (KIN59) Biochem Pharmacol 78 231-240

[6] van Hinsbergh VW(2009)The dual role of thymidine phosphorylase in cancer development and chemotherapy Med Res Rev 29 903-953

[7] Boven E(1998)Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis Biochem J 334 1-8

[8] Bijnsdorp IV(2000)Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors Cancer Res 60 6298-6302

[9] Azijli K(2007)Targeting the mTOR signaling network in cancer Trends Mol Med 13 433-442

[10] Jansen EE(2004)Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells Mol Pharmacol 66 1054-1060

[1] Ackland SP(1999)Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs Drug Resist Update 2 205-214

[2] Peters GJ(2006)Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton Mol Cancer Ther 5 2348-2357

[3] Bijman MN(2010)Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells Biochem Pharmacol 80 786-792

[4] van Nieuw Amerongen GP(2010)Increased migration by stimulation of thymidine phosphorylase in endothelial cells of different origin Nucleosides Nucleotides Nucleic Acids 29 482-487

[5] Laurens N(2009)Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule ‘crystallization chaperone’ 5′-O-tritylinosine (KIN59) Biochem Pharmacol 78 231-240

[6] van Hinsbergh VW(2009)The dual role of thymidine phosphorylase in cancer development and chemotherapy Med Res Rev 29 903-953

[7] Boven E(1998)Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis Biochem J 334 1-8

[8] Bijnsdorp IV(2000)Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors Cancer Res 60 6298-6302

[9] Azijli K(2007)Targeting the mTOR signaling network in cancer Trends Mol Med 13 433-442

[10] Jansen EE(2004)Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells Mol Pharmacol 66 1054-1060