Antiproliferative activity of ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids

被引：0
作者：
Li Sun
Xiang-Wu Chu
Chun-mei Liu
Li-Xin Sheng
Zhuan-Xin Chen
Ke-Guang Cheng
机构：
[1] State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources,
[2] School of Chemistry and Pharmacy of Guangxi Normal University,undefined
来源：
Medicinal Chemistry Research | 2019年 / 28卷
关键词：
Ursolic acid; Glycyrrhetinic acid; Uracil; Thymine; Antiproliferative activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
As pharmacophore hybridization has been used frequently in the discovery of new drugs, ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids have been synthesized and evaluated their antiproliferative activity by the MTT assay. The results displayed that, the hybrids of glycyrrhetinic acid (7a–7b to 10a–10b) exhibited slightly better antiproliferative activity than that of ursolic acid hybrids (3a–3b to 6a–6b). Two single glycyrrhetinic acid-thymine hybrids (8a and 10a) possessed good antiproliferative activity against tested A549 cell line (IC50 = 10.7 and 18.3 µM, respectively). And three hybrids (3a, 5a, and 10b) exhibited about 80% inhibitory ratio against tested Hela cell line.
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页码：892 / 899
页数：7
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