NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition

[1] Hockel M(1993)Intratumoral Po2 predicts Survival in Advanced Cancer of the Uterine Cervix Radiother Oncol 26 45-50

[2] Hockel M(1996)Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix Cancer Res 56 4509-15

[3] Hockel M(2001)Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects Jnci-Journal of the National Cancer Institute 93 266-76

[4] Vaupel P(2007)Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: a review Clin Otolaryngol 32 337-45

[5] Silva P(2001)Oxygenation status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy Semin Oncol 28 29-35

[6] Vaupel P(2007)Hypoxia in cancer: significance and impact on clinical outcome Cancer Metastasis Rev 26 225-39

[7] Kelleher DK(2012)Acute versus chronic hypoxia in tumors: controversial data concerning time frames and biological consequences Strahlenther Onkol 188 616-27

[8] Hockel M(2010)Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1 Cell Cycle 9 2502-7

[9] Vaupel P(2017)Physiological Effects of Chronic Hypoxia N Engl J Med 376 1965-71

[10] Mayer A(2008)Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance Cancer Res 68 605-14

[1] Hockel M(1993)Intratumoral Po2 predicts Survival in Advanced Cancer of the Uterine Cervix Radiother Oncol 26 45-50

[2] Hockel M(1996)Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix Cancer Res 56 4509-15

[3] Hockel M(2001)Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects Jnci-Journal of the National Cancer Institute 93 266-76

[4] Vaupel P(2007)Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: a review Clin Otolaryngol 32 337-45

[5] Silva P(2001)Oxygenation status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy Semin Oncol 28 29-35

[6] Vaupel P(2007)Hypoxia in cancer: significance and impact on clinical outcome Cancer Metastasis Rev 26 225-39

[7] Kelleher DK(2012)Acute versus chronic hypoxia in tumors: controversial data concerning time frames and biological consequences Strahlenther Onkol 188 616-27

[8] Hockel M(2010)Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1 Cell Cycle 9 2502-7

[9] Vaupel P(2017)Physiological Effects of Chronic Hypoxia N Engl J Med 376 1965-71

[10] Mayer A(2008)Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance Cancer Res 68 605-14