Insulin Effects on Survival of Human Multiple Myeloma Cells

被引：0
作者：
S. S. Shushanov
T. A. Kravtsova
Yu. B. Chernykh
N. N. Cheikina
机构：
[1] Russian Academy of Medical Sciences,Research Institute of Carcinogenesis, N. N. Blokhin Russian Cancer Research Center
来源：
Bulletin of Experimental Biology and Medicine | 2015年 / 159卷
关键词：
multiple myeloma; insulin; cell survival; mRNA expression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Insulin effects of human multiple myeloma cell survival were studied on RPMI1640, RPMI8226, and IM9 lines differing by differentiation degree. The effects of exogenous insulin on tumor cell growth and survival varied. Insulin alone did not improve the viability of myeloma cells, while in combination with serum growth factors increased it. The IM9 cells with immunophenotype (CD138+, CD38–, CD45+, CD56–, CD19+) exhibited the highest sensitivity to serum growth factors, while RPMI1640 and RPMI8226 cells with (CD138+, CD38+, CD45–, CD56±, CD19–) immunophenotype were less sensitive. Studies of gene expression showed a significantly lower level of IRA mRNA expression in IM9 vs. RPMI1640 and RPMI8226 cells.
引用
收藏
页码：262 / 265
页数：3
相关论文
共 50 条
  • [21] Tumor necrosis factor is a survival and proliferation factor for human myeloma cells
    Jourdan, M
    Tarte, K
    Legouffe, É
    Brochier, J
    Rossi, JF
    Klein, B
    EUROPEAN CYTOKINE NETWORK, 1999, 10 (01) : 65 - 70
  • [22] Toll-like receptors mediate proliferation and survival of multiple myeloma cells
    Bohnhorst, J
    Rasmussen, T
    Moen, SH
    Flottum, M
    Knudsen, L
    Borset, M
    Espevik, T
    Sundan, A
    LEUKEMIA, 2006, 20 (06) : 1138 - 1144
  • [23] Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells
    K Bauer
    A K Kretzschmar
    H Cvijic
    C Blumert
    D Löffler
    K Brocke-Heidrich
    C Schiene-Fischer
    G Fischer
    A Sinz
    C V Clevenger
    F Horn
    Oncogene, 2009, 28 : 2784 - 2795
  • [24] Recombinant human erythropoietin is associated with increased overall survival in patients with multiple myeloma
    Baz, R.
    Walker, E.
    Choueiri, T. K.
    Abou Jawde, R.
    Brand, C.
    McGowan, B.
    Yiannaki, E.
    Andresen, S.
    Hussein, M. A.
    ACTA HAEMATOLOGICA, 2007, 117 (03) : 162 - 167
  • [25] Synergistic Apoptotic Effects of Bortezomib and Methylstat on Multiple Myeloma Cells
    Kaci, Fatma Necmiye
    Kiraz, Yagmur
    Cekdemir, Demet
    Baran, Yusuf
    ARCHIVES OF MEDICAL RESEARCH, 2020, 51 (03) : 187 - 193
  • [26] Toll-like receptors mediate proliferation and survival of multiple myeloma cells
    J Bohnhorst
    T Rasmussen
    S H Moen
    M Fløttum
    L Knudsen
    M Børset
    T Espevik
    A Sundan
    Leukemia, 2006, 20 : 1138 - 1144
  • [27] In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates
    A Aparicio
    A Gardner
    Y Tu
    A Savage
    J Berenson
    A Lichtenstein
    Leukemia, 1998, 12 : 220 - 229
  • [28] In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates
    Aparicio, A
    Gardner, A
    Tu, Y
    Savage, A
    Berenson, J
    Lichtenstein, A
    LEUKEMIA, 1998, 12 (02) : 220 - 229
  • [29] Effect of the amount of Autologous Hematopoietic Stem Cells on Survival and Engraftment in Multiple Myeloma
    Batgi, Hikmettullah
    Basci, Semih
    Bakirtas, Mehmet
    Ulu, Bahar Uncu
    Yigenoglu, Tugce Nur
    Yildiz, Jale
    Iskender, Dicle
    Ozcan, Nurgul
    Dal, Mehmet Sinan
    Cakar, Merih Kizil
    Altuntas, Fevzi
    IRANIAN RED CRESCENT MEDICAL JOURNAL, 2021, 23 (05)
  • [30] Marital Status and Survival in Patients with Multiple Myeloma: The Role of Marriage in the Management of Multiple Myeloma
    Islam, Serajul
    Lee, Chansoon
    Kim, Jichan
    Enright, Robert
    Kotoucek, Pavel
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 (10) : E259 - E260
12345