Genomic risk factors in sudden infant death syndrome

被引：0
作者：
David W Van Norstrand
Michael J Ackerman
机构：
[1] Mayo Clinic,Department of Molecular Pharmacology and Experimental Therapeutics
[2] Mayo Clinic,Departments of Medicine and Pediatrics, Divisions of Cardiovascular Diseases and Pediatric Cardiology, and the Windland Smith Rice Sudden Death Genomics Laboratory
来源：
Genome Medicine | / 2卷
关键词：
Sudden Infant Death Syndrome; Brugada Syndrome; Catecholaminergic Polymorphic Ventricular Tachycardia; Sudden Infant Death Syndrome Case; Cardiac Sodium Channel;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sudden infant death syndrome (SIDS) is a major contributor to postneonatal infant death, and is the third leading cause of infant mortality in the USA. While public health efforts have reduced these deaths in recent years, the pathogenesis of SIDS remains unclear. Epidemiological data on SIDS-related deaths have suggested genetic factors, and many studies have attempted to identify SIDS-associated genes. This has resulted in a large body of literature implicating various genes and their encoded proteins and signaling pathways in numerous cohorts of various sizes and ethnicities. This review has undertaken a systematic evaluation of these studies, identifying the pathways that have been implicated in these studies, including central nervous system pathways, cardiac channelopathies, immune dysfunction, metabolism/energy pathways, and nicotine response. This review also explores how new genomic techniques will aid in advancing our knowledge of the genomic risk factors associated with SIDS, including SNPs and copy number variation. Last, this review explores how the current information can be applied to aid in our assessment of the at risk infant population.
引用
收藏
相关论文
共 559 条
  • [1] Kinney HC(2009)The sudden infant death syndrome N Engl J Med 361 795-805
  • [2] Thach BT(1991)Defining the sudden infant death syndrome (SIDS): deliberations of an expert panel convened by the National Institute of Child Health and Human Development Pediatr Pathol 11 677-684
  • [3] Willinger M(2002)The triple risk hypotheses in sudden infant death syndrome Pediatrics 110 e64-1869
  • [4] James LS(2006)Sudden infant death syndrome CMAJ 174 1861-32
  • [5] Catz C(2007)Infant mortality statistics from the 2004 period linked birth/infant death data set Natl Vital Stat Rep 55 1-1587
  • [6] Guntheroth WG(2007)Sudden infant death syndrome Lancet 370 1578-268
  • [7] Spiers PS(2002)Evaluation of diagnostic tools applied in the examination of sudden unexpected deaths in infancy and early childhood Forensic Sci Int 125 262-443
  • [8] Hunt CE(1999)Sudden unexpected deaths in infancy: what are the causes? J Pediatr 135 437-574
  • [9] Hauck FR(1989)Early childhood mortality in Cape Town S Afr Med J 75 570-1265
  • [10] Mathews TJ(1970)Postmortem leukocyte culture studies in sudden infant death Nature 226 1264-396
12345678910