Gastroprotective effect of mummy on induced gastric ulcer in rats

被引：0
作者：
Abshenas J. [1 ,3 ]
Kheirandish R. [2 ,3 ]
Salary A.R. [3 ]
机构：
[1] Department of Clinical Sciences, Shahid Bahonar University of Kerman, Kerman
[2] Department of Pathobiology, Shahid Bahonar University of Kerman, Kerman
[3] Shahid Bahonar University of Kerman, Kerman
来源：
Comparative Clinical Pathology | 2014年 / 23卷 / 2期
关键词：
Ethanol; Gastric ulcer; Gastroprotective; Mummy; Rat;
D O I：
10.1007/s00580-012-1610-7
中图分类号：
学科分类号：
摘要：
Mummy was used in traditional medicine as a remedy for inflammation, articular injuries, rheumatism, bone fractures, wounds and back pains. In previous research, the healing effects of mummy on a rabbit's tibial fracture were studied, and the results supported its efficacy. In consideration of claims and suggestions by traditional medicine about the effectiveness of mummy on wound healing, the present study was aimed at investigating the protective effect of mummy on gastric ulcer induced by ethanol. Young male albino rats (NMRI strain, n = 21, 190-230 g body weight) were randomly divided into three experimental groups: treatment group, positive control group and negative control group, each containing seven rats. All animals had been exposed to starvation for 24 h and then received oral ethanol (1 ml/200 g body weight). The treatment group received 100 mg/kg/day mummy; the positive control group received 200 mg/kg/day cimethidine, and the negative control group received 5 ml/kg/day distilled water for 2 weeks by gavages. One hour after the last treatment, all animals were killed, and their stomachs were dissected. The number and length of ulcers were determined using stereomicroscope; then graticule and the ulcer index and curative ratio were calculated. Data was analysed using one-way ANOVA and Tukey's post hoc test. The administration of mummy significantly decreased the gastric ulcer score and ulcer index in the treatment group, compared with the positive control and negative control groups. The curative ratio in the treatment group was significantly higher than the negative control and the positive control groups (89.26 versus 87.79 %, respectively). The results showed excellent effects of mummy on wound healing after the ethanol-induced gastric ulcer in rats. © 2012 Springer-Verlag London Limited.
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页码：305 / 309
页数：4
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