Alterations of the collagenous structure of human heart valves as a function of age and hypertension [Veräinderungen der kollagenen strukturen menschlicher herzklappen in abháingigkeit von alter und hypertonie]

被引：0

作者：

Keller F. ^{[1
]}

Pflug A. ^{[1
]}

Lehmann Y. ^{[1
]}

机构：

[1] Institut für Anatomie, Universität Leipzig, 04103 Leipzig

来源：

Zeitschrift für Gerontologie und Geriatrie | 2001年 / 34卷 / 6期

关键词：

Age dependence; Atrioventricular valves; Collagen types I and III; Hypertension; Relative collagen content;

D O I：

10.1007/s003910170021

中图分类号：

学科分类号：

摘要：

Using polarization microscopy and morphometrical methods, the influence of hypertension on the collagenous structures in the Lamina fibrosa of bicuspid valves of 14 middle-aged persons (30 to 50 years) were examined. The measurements were performed on histological sections. A group of 14 middle-aged subjects free from heart disease served as the control group. Furthermore, the results were compared to earlier findings on the histological biomorphosis of the atrioventricular valves. The following changes were observed and quantitatively determined: a) an enhancement of the percentage of the mechanically more resistent collagenous fibers (unsilvered, type I collagen), b) a stronger lateral aggregation of the collagenous fibrils of both types I and III collagen, c) a significant decrease of the total numbers of collagenous fibers per measuring area, and d) a significant decrease of the portion of silvered fibers (type III collagen) per measuring area for both sexes. The fiber density distributions confirm the observed changes: in the hypertension group the collagenous fibers are less densly distributed than in the control group. The observed regression of the content of collagenous fibers in the hypertension group is probably due to the anti-hypertensive treatment. Following the findings the turn-over of type III collagen is stronger influenced than that of type I collagen. The initial results determined in human heart valves confirm findings in animal models and characterize them with regard to the collagen types mentioned.

引用

页码：470 / 475

页数：5

共 18 条

[1]

Brilla C.G., Janicki J.S., Weber K.T., Cardioreparative effects of Lisinopril in rats with genetic hypertension and left ventricular hypertrophy, Circulation, 83, 5, pp. 1771-1779, (1991)

[2]

Doerfer K., Einfluss unterschiedlicher Therapieformen auf den myokardialen Kollagengehalt nach experimentellem Myokardinfarkt, (1996)

[3]

Kaplan N.M., Clinical hypertension, (1998)

[4]

Keller F., Leutert G., Untersuchungen zu alternsveränderungen am kollagen verschiedener organe - Kombinierte polarisationsmikroskopische, morphometrische und immunhistochemische auswertung, Altern in Gesundheit und Krankheit, 13, pp. 241-245, (1997)

[5]

Keller F., Dumstrey T., Giesler T., Leutert G., Polarisationsmikroskopische untersuchungen zur kollagen-zusammensetzung der chordae tendineae des menschlichen herzens: Abhängigkeit von druck und lebensalter, Ann Anat, 181, SUPPL., pp. 120-121, (1999)

[6]

Keller F., Werner R., Wahner J., Et al., Zur histologischen biomorphose menschlicher herzklappen II. Morphometrische untersuchungen, Z Gerontol Geriat, 32, pp. 104-111, (1999)

[7]

Kohler T., Morphometrische Untersuchungen zu Alternsveränderungen menschlicher Herzklappen - Ein Vergleich zwischen Valva bicuspidalis und Valva tricuspidalis anamnestisch herzgesunder Personen, (2000)

[8]

Leutert G., Morphologische alternsveränderungen des herzens und der gefäße - Ein beitrag zum asynchronen altern der organe und gewebe des menschen, Ztschr f d gesamte Innere Medizin und ihre Grenzgebiete, 31, 4, pp. 97-104, (1976)

[9]

Leutert G., Schwarz H., Keller F., Untersuchungen zum kollagenpolymorphismus der valva bicuspidalis, Verh Anat Ges, 81, pp. 65-66, (1987)

[10]

Leutert G., Keller F., Histophysical methods for the investigation of various collagen types with regard to age, The theoretical basis of aging research, pp. 185-191, (1990)

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