Beyond Coronary Stenosis: Coronary Computed Tomographic Angiography for the Assessment of Atherosclerotic Plaque Burden

被引:25
作者
Kwan A.C. [1 ]
Cater G. [2 ]
Vargas J. [1 ]
Bluemke D.A. [1 ]
机构
[1] Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, 20892-1182, 10 Center Drive, Building 10
[2] Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 44195
基金
美国国家卫生研究院;
关键词
Acute coronary syndrome; Atherosclerosis; Coronary artery calcium; Coronary computed tomographic angiography; CT; Non-calcified; Plaque; Reconstruction; Spotty calcification; Vulnerable plaque;
D O I
10.1007/s12410-012-9183-z
中图分类号
学科分类号
摘要
Coronary computed tomographic angiography (CCTA) is emerging as a key noninvasive method for assessing cardiovascular risk by measurement of coronary stenosis and coronary artery calcium (CAC). New advancements in CCTA technology have led to the ability to directly identify and quantify the so-called "vulnerable" plaques that have features of positive remodeling and low density components. In addition, CCTA presents a new opportunity for noninvasive measurement of total coronary plaque burden that has not previously been available. The use of CCTA needs also to be balanced by its risks; in particular, the associated radiation exposure. We review current uses of CCTA, CCTA's ability to measure plaque quantity and characteristics, and new developments in risk stratification and CCTA technology. CCTA represents a quickly developing field that will play a growing role in the non-invasive management of cardiovascular disease. © 2013 Springer Science+Business Media New York (outside the USA).
引用
收藏
页码:89 / 101
页数:12
相关论文
共 130 条
[1]  
Lloyd-Jones D., Adams R.J., Brown T.M., Carnethon M., Dai S., de Simone G., Et al., Heart disease and stroke statistics-2010 update: a report from the American Heart Association, Circulation, 121, (2010)
[2]  
Lerner D.J., Kannel W.B., Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population, Am Heart J, 111, pp. 383-390, (1986)
[3]  
Stone G.W., Maehara A., Lansky A.J., Bruyne B., Cristea E., Mintz G.S., Et al., A prospective natural-history study of coronary atherosclerosis, N Engl J Med, 364, pp. 226-235, (2011)
[4]  
Pundziute G., Schuijf J.D., Jukema J.W., Decramer I., Sarno G., Vanhoenacker P.K., Et al., Evaluation of plaque characteristics in acute coronary syndromes: noninvasive assessment with multi-slice computed tomography and invasive evaluation with intravascular ultrasound radiofrequency data analysis, Eur Heart J, 29, pp. 2373-2381, (2008)
[5]  
Rioufol G., Finet G., Andre-Fouet X., Rossi R., Vialle E., Desjoyaux E., Multiple ruptures of atherosclerotic plaques in acute coronary syndrome. Endocoronary ultrasonography study of 3 arteries, Arch Mal Coeur Vaiss, 95, pp. 157-165, (2002)
[6]  
Rioufol G., Finet G., Ginon I., Andre-Fouet X., Rossi R., Vialle E., Et al., Multiple atherosclerotic plaque rupture in acute coronary syndrome: a 3-vessel intravascular ultrasound study, Circulation, 106, pp. 804-808, (2002)
[7]  
Tanaka A., Shimada K., Yoshida K., Jissyo S., Tanaka H., Sakamoto M., Et al., Non-invasive assessment of plaque rupture by 64-slice multidetector computed tomography-comparison with intravascular ultrasound, Circ J, 72, (2008)
[8]  
Kashiwagi M., Tanaka A., Kitabata H., Tsujioka H., Kataiwa H., Komukai K., Et al., Feasibility of noninvasive assessment of thin-cap fibroatheroma by multidetector computed tomography, JACC Cardiovasc Imaging, 2, pp. 1412-1419, (2009)
[9]  
Maurovich-Horvat P., Hoffmann U., Vorpahl M., Nakano M., Virmani R., Alkadhi H., The napkin-ring sign: CT signature of high-risk coronary plaques?, JACC Cardiovasc Imaging, 3, (2010)
[10]  
Seifarth H., Schlett C.L., Nakano M., Otsuka F., Karolyi M., Liew G., Et al., Histopathological correlates of the napkin-ring sign plaque in coronary CT angiography, Atherosclerosis, 224, 1, pp. 90-96, (2012)