Plasmablastic Lymphoma of Head and Neck: Report of Two New Cases and Correlation with c-myc and IgVH Gene Mutation Status

被引：9

作者：

Hassan A. ^{[1
]}

Kreisel F. ^{[1
]}

Gardner L. ^{[2
]}

Lewis Jr. J.S. ^{[1
]}

El-Mofty S.K. ^{[1
]}

机构：

[1] Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University School of Medicine, St. Louis, MO 63110, Campus Box 8118

[2] Department of Pathology, St. Louis University School of Medicine, St. Louis

来源：

Head and Neck Pathology | 2007年 / 1卷 / 2期

关键词：

Acquired immunodeficiency syndrome-associated non- Hodgkin's lymphoma; c-myc gene rearrangement; Immunoglobulin variable heavy chain hypermutation status; Plasmablastic lymphoma;

D O I：

10.1007/s12105-007-0006-5

中图分类号：

学科分类号：

摘要：

Plasmablastic lymphoma (PBL) is a rare acquired immunodeficiency syndrome-associated non- Hodgkin's lymphoma (AIDS-NHL), with predilection for the mucosa of oral cavity. It usually has a plasmablastic morphology, expressing plasma cell-associated antigens with weak or absent expression of B-cell-associated markers. To further define the immunophenotypic and molecular genetics of these tumors, we investigated two cases of plasmablastic lymphomas of the head and neck for c-myc gene rearrangement and immunoglobulin heavy chain (IgVH) hypermutation status. For the first time we report a case of AIDS-related PBL that, by fluorescence in situ hybridization (FISH), shows a c-myc gene rearrangement. Although current literature suggests that most cases of c-myc gene rearranged AIDS-NHL are Burkitt's lymphoma, our case has an immunophenotype characteristic for PBL. In this case, IgVH hypermutation analysis showed a somatic hypermutation, indicative of germinal center transit. The concurrent B-cell immunophenotype of BCL-6-/CD138+MUM-1+ also suggests a post-germinal center B-cell origin of this lymphoma. The immunophenotype of our second case (BCL-6-/CD138+/MUM-1+) also suggests a post-germinal center B-cell origin. However, IgVH hypermutation analysis was not possible in this case.© Humana Press Inc. 2007.

引用

页码：150 / 155

页数：5

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