Advances of nanoparticles in transmucosal drug delivery

被引：0
作者：
Li Zhang
Changwei Yang
Yingxiang Song
Tao Sheng
Junyan Li
Jicheng Yu
Xiaohong Wu
Xiao Ye
机构：
[1] Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital,Geriatric Medicine Center, Department of Endocrinology
[2] Hangzhou Medical College),Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences
[3] Zhejiang University,Liangzhu Laboratory
[4] Jinhua Institute of Zhejiang University,Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine
[5] Zhejiang University Medical Center,National Key Laboratory of Advanced Drug Delivery and Release Systems
[6] Zhejiang University,undefined
[7] Zhejiang University,undefined
[8] Key Laboratory for Diagnosis and Treatment of Endocrine Gland Diseases of Zhejiang Province,undefined
来源：
Nano Research | 2024年 / 17卷
关键词：
nanoparticles (NPs); transmucosal drug delivery; mucosal barriers; biomaterials;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therapeutics directly to the target disease site. However, many challenges still remain in its clinical application, including low drug availability and limited retention time in the mucosa. The burgeoning advancement of nanotechnologies offers great potential to overcome the above limitations, leveraging their distinct advantages of high drug-loading capacity and strong permeability. In this review, the latest developments of nanoparticles (NPs) in transmucosal drug delivery as well as their clinical applications are discussed.
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页码：2874 / 2885
页数：11
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