Absolute quantification of high energy phosphate metabolites in normal, hypertrophied and failing human myocardium

被引：0
作者：
Stefan Neubauer
Meinrad Beer
Wilfried Landschütz
Jörn Sandstede
Tobias Seyfarth
Claudia Lipke
Herbert Köstler
Thomas Pabst
Werner Kenn
Martin Meininger
Markus von Kienlin
Michael Horn
Kerstin Harre
Dietbert Hahn
机构：
[1] Oxford University,Department of Cardiovascular Medicine
[2] Würzburg University,Institut für Röntgendiagnostik, Physikalisches Institut V, Medizinische Klinik
[3] John Radcliffe Hospital,Department of Cardiovascular Medicine
[4] Headley Way,undefined
来源：
Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine | 2000年 / 11卷 / 1-2期
关键词：
Myocardium; MR-spectroscopy; Cardiomyopathy; Stenosis;
D O I：
10.1007/BF02678501
中图分类号：
学科分类号：
摘要：
For definitive conclusions, larger numbers of patients will have to be studied, but our preliminary results indicate that (1) ATP levels decline in heart failure but not in left ventricular hypertrophy and (2) phosphocreatine/ATP ratios underestimate the true changes in myocardial high-energy phosphate concentrations in chronically injured human myocardium.
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页码：73 / 74
页数：1
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共 60 条
[1]  
Hardy CJ(1991)Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy Am Heart J 122 795-801
[2]  
Weiss RG(1991)Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopy Lancet 338 973-6
[3]  
Bottomley PA(1992)31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Altered cardiac high-energy phosphate metabolism in heart failure Circulation 86 1810-8
[4]  
Gerstenblith G(1995)Contributions of 31P-magneic resonance spectroscopy to the understanding of dilated heart muscle disease Eur Heart J 16 115-8
[5]  
Conway MA(1997)In patients with dilated cardiomyopathy the myocardial phosphocreatine-to-ATP ratio is a predictor of mortality Circulation 96 2190-6
[6]  
Allis J(1990)Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance Magn Reson Med 14 425-34
[7]  
Ouwerkerk R(1996)Human cardiac high-energy phosphate metabolite concentrations by ID-resolved NMR spectroscopy Magn Reson Med 35 664-70
[8]  
Niioka T(1991)Spectral localization with optimal pointspread function Magn Reson Med 94 268-87
[9]  
Rajagopalan B(1999)Concentrations of human cardiac phosphorus metabolites determined by SLOOP 31P NMR spectroscopy Magn Reson Med 41 657-63
[10]  
Radda GK(1993)Is cardiac failure a consequence of decreased energy reserve? Circulation 87 58-62
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