Ten years of anti-vascular endothelial growth factor therapy

被引：0
作者：
Napoleone Ferrara
Anthony P. Adamis
机构：
[1] University of California,
[2] San Diego,undefined
[3] Genentech,undefined
[4] Inc.,undefined
来源：
Nature Reviews Drug Discovery | 2016年 / 15卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Over the past 10 years, targeting vascular endothelial growth factor A (VEGFA) has been widely pursued in the treatment of various cancers and ophthalmic diseases. Here, Ferrara and Adamis provide an overview of the discovery of VEGFA and the development of anti-VEGFA therapies, addressing key challenges and issues that remain in the application of these agents.
引用
收藏
页码：385 / 403
页数：18
相关论文
共 456 条
  • [51] Ferrara N(2006)Molecular control of endothelial cell behaviour during blood vessel morphogenesis Nat. Cell Biol. 8 1223-1234
  • [52] Gerber HP(2012)Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele J. Exp. Med. 209 1363-1377
  • [53] LeCouter J(2003)Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene Nat. Med. 9 685-693
  • [54] Neufeld G(2009)Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice Br. J. Cancer 100 865-869
  • [55] Cohen T(1996)Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice Ophthalmology 103 1820-1828
  • [56] Gengrinovitch S(2008)Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability N. Engl. J. Med. 358 2039-2049
  • [57] Poltorak Z(2006)Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability Clin. Cancer Res. 12 5018-5022
  • [58] Ferrara N(2008)VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin Nat. Rev. Cancer 8 579-591
  • [59] Bates DO(1992)VEGFR2 induces c-Src signaling and vascular permeability Growth Factors 7 53-64
  • [60] Eswarappa SM(1995) via the adaptor protein TSAd J. Clin. Invest. 95 1789-1797
12345678910