Ten years of anti-vascular endothelial growth factor therapy

被引:0
作者
Napoleone Ferrara
Anthony P. Adamis
机构
[1] University of California,
[2] San Diego,undefined
[3] Genentech,undefined
[4] Inc.,undefined
来源
Nature Reviews Drug Discovery | 2016年 / 15卷
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摘要
Over the past 10 years, targeting vascular endothelial growth factor A (VEGFA) has been widely pursued in the treatment of various cancers and ophthalmic diseases. Here, Ferrara and Adamis provide an overview of the discovery of VEGFA and the development of anti-VEGFA therapies, addressing key challenges and issues that remain in the application of these agents.
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页码:385 / 403
页数:18
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  • [1] Folkman J(1987)Angiogenic factors Science 235 442-447
  • [2] Klagsbrun M(2002)VEGF and the quest for tumour angiogenesis factors Nat. Rev. Cancer 2 795-803
  • [3] Ferrara N(1939)Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber Am. J. Roentgenol. 42 891-899
  • [4] Ide AG(1945)Vascular reactions of normal and malignant tissues J. Natl Cancer Inst. 6 73-85
  • [5] Baker NH(1971) I. Vascular reactions of mice to wounds and to normal and neoplastic transplants N. Engl. J. Med. 285 1182-1186
  • [6] Warren SL(1991)Tumor angiogenesis: therapeutic implications Annu. Rev. Physiol. 53 217-239
  • [7] Algire GH(1989)Regulators of angiogenesis Science 246 1306-1309
  • [8] Chalkley HW(1989)Vascular endothelial growth factor is a secreted angiogenic mitogen Science 246 1309-1312
  • [9] Legallais FY(2004)Vascular permeability factor, an endothelial cell mitogen related to PDGF Endocr. Rev. 25 581-611
  • [10] Park HD(2010)Vascular endothelial growth factor: basic science and clinical progress Nat. Med. 16 1107-1111