Down-regulation of tumor suppressor in lung cancer 1 (TSLC1) expression correlates with poor prognosis in patients with colon cancer

被引：0
作者：
Jinfeng Zhang
Jinfeng Ning
Jingshu Geng
Binbin Cui
Xinshu Dong
机构：
[1] The Third Affiliated Hospital of Harbin Medical University,Department of Thoracic Surgery
[2] The Fourth Affiliated Hospital of Harbin Medical University,Department of Oncology
[3] The Third Affiliated Hospital of Harbin Medical University,Department of Pathology
[4] The Third Affiliated Hospital of Harbin Medical University,Department of Gastrointestinal Surgery
来源：
Journal of Molecular Histology | 2012年 / 43卷
关键词：
Tumor suppressor in lung cancer 1; Colon cancer; Prognosis; Human;
D O I：
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中图分类号：
学科分类号：
摘要：
Tumor suppressor in lung cancer 1 (TSLC1), a novel tumor suppressor gene, has been reported to be frequently inactivated in a variety of human malignant tumors. The aim of this study was to detect TSLC1 expression in human colon cancer and to analyze its association with prognosis of patients with colon cancer. Using quantitative real-time PCR and Western blot analysis, we found significantly decreased expression of TSLC1 in primary colon tumor tissues (n = 30) compared with adjacent normal tissues. Immunohistochemistry analysis also found decreased TSLC1 expression in 41.3 % (33/80) colon tumor tissues. In clinicopathological analysis, loss of TSLC1 expression significantly correlated with female gender and lymph node metastasis of colon cancer patients (P < 0.05). In addition, decreased expression of TSLC1 in tumors was found to be closely associated with a poor prognosis (P = 0.037, log-rank test), and multivariate analysis showed that lower TSLC1 protein expression was an independent prognostic factor for colon cancer patients. Our study suggests that down-regulated expression of TSLC1 may play an important role in the progression of colon cancer and TSLC1 expression may serve as a useful marker for the prognostic evaluation of patients with colon cancer.
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页码：715 / 721
页数：6
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共 191 条
[1]  
Ando K(2008)Expression of TSLC1, a candidate tumor suppressor gene mapped to chromosome 11q23, is downregulated in unfavorable neuroblastoma without promoter hypermethylation Int J Cancer 123 2087-2094
[2]  
Ohira M(2011)CADM1/TSLC1 inactivation by promoter hypermethylation is a frequent event in colorectal carcinogenesis and correlates with late stages of the disease Int J Cancer 128 266-273
[3]  
Ozaki T(2003)Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines Int J Cancer 107 53-59
[4]  
Nakagawa A(2005)Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance Cancer Sci 96 480-486
[5]  
Akazawa K(2007)Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer Breast Cancer Res Treat 103 283-291
[6]  
Suenaga Y(2010)A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics Clin Exp Metastasis 27 83-90
[7]  
Nakamura Y(2003)Epigenetic inactivation of TSLC1 gene in nasopharyngeal carcinoma Mol Carcinog 38 170-178
[8]  
Koda T(2003)Involvement of TSLC1 in progression of esophageal squamous cell carcinoma Cancer Res 63 6320-6326
[9]  
Kamijo T(2002)Aberrant methylation of the 5′ CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs Cancer Biol Ther 1 293-296
[10]  
Murakami Y(2011)Global cancer statistics CA Cancer J Clin 61 69-90
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