E-cadherin as a prognostic indicator in primary breast cancer

被引：0
作者：
C Parker
R S Rampaul
S E Pinder
J A Bell
P M Wencyk
R W Blamey
R I Nicholson
J F R Robertson
I O Ellis
机构：
[1] University Of Nottingham,Department of Histopathology
[2] City Hospital,Department of Surgery
[3] Nottingham NHS Trust,undefined
[4] University Of Nottingham,undefined
[5] City Hospital,undefined
[6] Nottingham NHS Trust,undefined
[7] Tenovus Institute,undefined
来源：
British Journal of Cancer | 2001年 / 85卷
关键词：
Breast cancer; immunohistochemistry; cadherin; prognosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Epithelial cadherin (E-CD) is a member of the cadherin family of cell adhesion molecules and has been implicated as an invasion suppressor molecule in vitro and in vivo. We analysed 174 breast tumours from the Nottingham/Tenovus Breast Cancer Series immunohistochemically for E-CD expression using the mouse monoclonal antibody HECD-1 (Zymed Laboratories Inc.). In normal epithelial cells E-CD was strongly expressed at cell–cell boundaries. 66% of the breast cancers examined had reduced intensity of E-CD expression with 74% having significant reductions in the proportion of E-CD-positive tumour cells. Using a combined intensity/proportion score, significant associations were found between E-CD expression and tumour type (P ≤ 0.001). ER status (P = 0.026) and histological grade (P = 0.031). Expression of E-CD was not found to be related to recurrence, distant metastases, lymph node stage, vascular invasion, primary tumour size, prognostic group or survival. Thus E-CD expression in human breast cancer appears to have minimal prognostic value, but may have a role as a phenotypic marker. © 2001 Cancer Research Campaign http://www.bjcancer.com
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页码：1958 / 1963
页数：5
相关论文
共 182 条
[1]  
Becker KF(1999)Identification of eleven novel tumour-associated E-cadherin mutations. Mutations in brief no. 215. Online Human Mutations 13 171-184
[2]  
Reich U(1993)The role of cell adhesion molecules in cancer invasion and metastasis Breast Cancer Res Treat 24 175-1925
[3]  
Schott C(1996)E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain Oncogene 13 1919-26
[4]  
Becker I(1994)Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness Biochim Biophys Acta 1198 11-4609
[5]  
Berx G(1994)Tamoxifen restores the E-Cadherin function in Human Breast Cancer MCF-7/6 Cells and Suppresses Their Invasive Phenotype Cancer Research 54 4607-1291
[6]  
van Roy F(1994)Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: Characterisation of the human E-Cadherin gene promoter Biochem Biophy Res Comm 203 1284-300
[7]  
Hofler H(1997)E-Cadherin quantitative immunocytochemical assays in breast carcinomas J of Path 181 294-986
[8]  
Behrens J(1993)E-Cadherin expression in colorectal cancer: An immunocytochemical and Am J of Pathol 142 981-489
[9]  
Berx G(1992) hybridisation study Histopathology 20 479-410
[10]  
Cleton-Jansen AM(1991)Pathological prognostic factors in breast cancer. II. Histological types. Relationship with survival in a large study with long term follow up Histopathology 19 403-993
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