Genes expression of metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis

被引：0
作者：
N. L. Starodubtseva
V. V. Sobolev
A. G. Soboleva
A. A. Nikolaev
S. A. Bruskin
机构：
[1] Moscow Institute of Physics and Technology,Vavilov Institute of General Genetics
[2] Russian Academy of Sciences,undefined
来源：
Russian Journal of Genetics | 2011年 / 47卷
关键词：
Psoriasis; Psoriasis Patient; Psoriatic Lesion; Primary Keratinocytes; Primary Human Keratinocytes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Using real-time polymerase chain reaction (RT-PCR), we measured mRNA amounts of matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-9, and MMP-12 genes in psoriatic lesions and unaffected skin of the same patients. We observed significant (about 15-fold) increase in the expression level of matrix metalloproteinase MMP-1 and MMP-12 genes associated with psoriasis. The results of our studies of MMP gene expression in cultured primary human keratinocytes treated with interleukin (IL)-17 have shown upregulation of MMP gene expression both in cultured keratinocytes and in psoriatic skin lesions. Therefore, upregulation of MMP genes in the skin affected by psoriasis could result from IL-17 effects on skin cells.
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页码：1117 / 1123
页数：6
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