The probability of acquiring primary Toxoplasma infection in HIV-infected patients: Results of an 8-year retrospective study

被引：2

作者：

Reiter-Owona I. ^{[1
]}

Bialek R. ^{[2
]}

Rockstroh J.K. ^{[3
]}

Seitz H.M. ^{[1
]}

机构：

[1] Inst. F. Medizinische Parasitologie, Universität Bonn, D-53127 Bonn

[2] Institut für Tropenmedizin, D-72074 Tübingen

[3] Medizinische Klinik, Universität Bonn, D-53127 Bonn

来源：

Infection | 1998年 / 26卷 / 1期

关键词：

Primary Infection; Toxoplasmosis; Toxoplasma Gondii; Toxoplasma Infection; Toxoplasma Encephalitis;

D O I：

10.1007/BF02768747

中图分类号：

学科分类号：

摘要：

There is much hope that HIV-infected patients and AIDS patients can reckon with a prolonged survival in future. The increased survival of AIDS patients with positive Toxoplasma serology is not necessarily associated with an increased risk of developing Toxoplasma encephalitis. For HIV-infected patients with negative Toxoplasma serology, the probability of acquiring a primary Toxoplasma infection in highly endemic areas such as Germany had not been studied to date. One hundred eighty-three HIV-infected patients were followed up between 1987 and 1995 in a retrospective study. Within the cohort, 95% of the patients were male and 83% haemophiliacs. The initial (1987) and final (1995) prevalence rate of Toxoplasma antibodies was 33.3% and 36.6%, respectively. The annual rise of the primary infection rate was calculated as 0.41%. The dye test was used for the detection of Toxoplasma-specific antibodies. This assay proved to be reliable and stable during long-term observation. The rate of primary toxoplasmosis found in this long-term study was not higher than that of pregnant women in Germany. Chemoprophylactic measurements for seronegative HIV-infected patients are therefore not recommended, but regular serological screening to detect seroconverters is.

引用

页码：20 / 25

页数：5

共 27 条

[1]

Grant H.I., Gold W.M., Rosenblum M., Niedzwiecki D., Armstrong D., Toxoplasma gondii serology in HIV-infected patients: The development of central nervous system toxoplasmosis in AIDS, AIDS, 4, pp. 519-521, (1990)

[2]

Pohle H.D., Toxoplasmose bei Immunsuppression, Toxoplasmose-Erreger und Krankheit, pp. 141-164, (1994)

[3]

Montaner J.S.G., Le Th., Hogg R., Ricketts M., Sutherland D., Strathdee St.A., O'Shaughnessy M., Schlechter M.T., The changing spectrum of AIDS index diseases in Canada, AIDS, 8, 5, pp. 693-695, (1994)

[4]

Berichte zur epidemiologischen Situation in der Bundesrepublik Deutschland zum 31. 12. 1995, RKI, 13, pp. 104-105, (1996)

[5]

Ockert G., Epidemiologie der Toxoplasmose, Infektionen Durch Toxoplasma Gondii, pp. 19-32, (1991)

[6]

Desmont G., Toxoplasmosis in France, Asian J. Clin. Sci., 7, pp. 89-109, (1987)

[7]

Aspock H., Flamm H., Picher O., Die Toxoplasmose-Überwachung während der Schwangerschaft. 10 Jahre Erfahrung in Österreich, Mitt. Österr. Ges. Tropenmed. Parasitol., 8, pp. 105-113, (1986)

[8]

Kovacs J.A., Toxoplasmosis in patients with acquired immunodeficiency syndrome, Opportunistic Infections in Patients with the Acquired Immunodeficiency Syndrome, pp. 343-354, (1989)

[9]

Luft B.J., Brooks R.G., Conley F.K., McCabe R.E., Remington J.S., Toxoplasma encephalitis in patients with acquired immune deficiency syndrome, JAMA, 252, pp. 913-917, (1984)

[10]

1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults, MMWR, 41, RR-17, pp. 1-19, (1992)

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