The Possibility of Cytochrome P450 1A1/1A2 Induction in Cells of Distant Lymph Nodes of Rats after Enteral Treatment with Benzo[a]pyrene

被引：0
|
作者：
Yu. I. Borodin
I. V. Maiborodin
A. F. Safina
D. N. Strunkin
机构：
[1] Russian Academy of Medical Sciences,Institute of Clinical and Experimental Lymphology, Siberian Division
来源：
Bulletin of Experimental Biology and Medicine | 2005年 / 140卷
关键词：
cytochrome P450; benzo[a]pyrene; lymph nodes; macrophages; endotheliocytes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The mesenteric, mediastinal, and popliteal lymph nodes of rats were studied by indirect immunoperoxidase method using monoclonal antibodies to cytochrome P450 1A1/1A2 after oral treatment with benzo[a]pyrene. These cytochrome forms were detected in monocytes, macrophages, reticular and littoral cells, cell detritus, and liquid contents of the paracortical and medullary sinuses of all studied lymph nodes. The results indicate that exo- and endogenous toxic substances are oxidized not only in the liver, but also in lymph nodes.
引用
收藏
页码：564 / 567
页数：3
相关论文
共 50 条
  • [1] The possibility of cytochrome P450 1A1/1A2 induction in cells of distant lymph nodes of rats after enteral treatment with benzo[a]pyrene
    Borodin, YI
    Maiborodin, IV
    Safina, AF
    Strunkin, DN
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2005, 140 (05) : 564 - 567
  • [2] Benzo[a]pyrene Induction of Cytochrome P450 1A1/1A2 in the Lymph Nodes of Rats
    Yu. I. Borodin
    A. F. Safina
    I. V. Maiborodin
    A. Yu. Grishanova
    Bulletin of Experimental Biology and Medicine, 2003, 136 : 611 - 614
  • [3] Benzo[a]pyrene induction of cytochrome P450 1A1/1A2 in the lymph nodes of rats
    Borodin, YI
    Safina, AF
    Maiborodin, IV
    Grishanova, AY
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2003, 136 (06) : 611 - 614
  • [4] Basal induction of cytochrome P-450 1A1/1A2 in cells of the liver, small intestinal villi, and lymph nodes in rats
    Borodin, Yu. I.
    Maiborodin, I. V.
    Safina, A. F.
    Strunkin, D. N.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2006, 141 (06) : 748 - 750
  • [5] Basal induction of cytochrome P-450 1A1/1A2 in cells of the liver, small intestinal villi, and lymph nodes in rats
    Yu. I. Borodin
    I. V. Maiborodin
    A. F. Safina
    D. N. Strunkin
    Bulletin of Experimental Biology and Medicine, 2006, 141
  • [6] Distribution and induction of cytochrome P450 1A1 and 1A2 in rat brain
    Morse, DC
    Stein, AP
    Thomas, PE
    Lowndes, HE
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1998, 152 (01) : 232 - 239
  • [7] INDUCTION OF CYTOCHROME-P450 1A1 AND 1A2 BY HYPEROXIA
    OKAMOTO, T
    MITSUHASHI, M
    FUJITA, I
    SINDHU, RK
    KIKKAWA, Y
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 197 (02) : 878 - 885
  • [8] Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition
    Walter M. A. Westerink
    Joe C. R. Stevenson
    Willem G. E. J. Schoonen
    Archives of Toxicology, 2008, 82 : 909 - 921
  • [9] Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition
    Westerink, Walter M. A.
    Stevenson, Joe C. R.
    Schoonen, Willem G. E. J.
    ARCHIVES OF TOXICOLOGY, 2008, 82 (12) : 909 - 921
  • [10] An amperometric biosensor based on rat cytochrome p450 1A1 for benzo[a]pyrene determination
    Wu, Yunhua
    Liu, Xuequn
    Zhang, Li
    Wang, Chuntai
    BIOSENSORS & BIOELECTRONICS, 2011, 26 (05): : 2177 - 2182
12345