Preventive Effects of Vanillic Acid on Lipids, Bax, Bcl-2 and Myocardial Infarct Size on Isoproterenol-Induced Myocardial Infarcted Rats: A Biochemical and In Vitro Study

被引：0
作者：
P. Stanely Mainzen Prince
K. Dhanasekar
S. Rajakumar
机构：
[1] Annamalai University,Department of Biochemistry and Biotechnology
来源：
Cardiovascular Toxicology | 2011年 / 11卷
关键词：
Vanillic acid; Isoproterenol; Lipids; Lipoproteins; Myocardial infarction;
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学科分类号：
摘要：
We made an attempt to evaluate the preventive effects of vanillic acid on isoproterenol-induced myocardial infarcted rats. Rats were pretreated with vanillic acid (5 and 10 mg/kg) daily for 10 days. After pretreatment, rats were injected with isoproterenol (100 mg/kg) at an interval of 24 h for 2 days to induce myocardial infarction. Isoproterenol induction increased the activity of serum creatine kinase-MB and increased the levels of serum and heart cholesterol, triglycerides, free fatty acids in rats. It increased the levels of serum low density and very low density lipoprotein cholesterol and decreased the levels of high-density lipoprotein cholesterol. Also, the activity of 3-hydroxy-3methyl glutaryl-coenzyme-A-reductase in the plasma and liver was increased, and lecithin cholesterol acyl transferase activity in the plasma and liver was decreased in isoproterenol-induced rats. Furthermore, isoproterenol-induced rats showed a decrease in myocardial expression of B-cell leukemia/lymphoma-2(bcl-2) gene and an increase in myocardial expression of bcl-2 associated-x (bax)-gene. Vanillic acid pretreated isoproterenol-induced rats positively altered all the above-mentioned biochemical parameters. Vanillic acid pretreatment also reduced myocardial infarct size in myocardial infarcted rats. In vitro study confirmed the potent free radical scavenging effect of vanillic acid. The observed effects are due to free radical scavenging effects of vanillic acid. This study may have a significant impact on myocardial infarcted patients.
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页码：58 / 66
页数：8
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  • [1] Sushama Kumari S(1989)Effect of carnitine on malondialdehyde, taurine and glutathione levels in heart of rats subjected to myocardial stress by isoproterenol Indian Journal of Experimental Biology 27 134-137
  • [2] Jayadeep A(2006)Efficacy of mangiferin on serum and heart tissue lipids in rats subjected to isoproterenol induced cardiotoxicity Toxicology 228 135-139
  • [3] Kumar JS(1984)Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol Journal of Lipid Research 25 1450-1461
  • [4] Menon VP(2006)How do cardiomyocytes die? Apoptosis and autophagic cell death in cardiac myocytes Journal of Cardiac Failure 12 381-391
  • [5] Prabhu SN(1992)Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene Science 258 302-304
  • [6] Shyamala Devi CS(1993)The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis Cell 73 295-307
  • [7] Goldstein JL(1997)Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development Development 124 4173-4178
  • [8] Brown MS(1998)Bcl-2 family: Regulators of cell death Annual Review of Immunology 16 395-419
  • [9] Kunapuli S(1996)A two-step bioconversion process for vanillin production from ferulic acid combining Journal of Biotechnology 50 107-113
  • [10] Rosanio S(2000) and Applied and Environmental Microbiology 66 2311-2317
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