The insulin-like growth factor pathway as a target for cancer therapy

被引：0
作者：
Iker López-Calderero
Elizabeth Sánchez Chávez
Rocío García-Carbonero
机构：
[1] Hospital Universitario Virgen del Rocío Instituto de Biomedicina de Sevilla (IBIS),Department of Medical Oncology
来源：
Clinical and Translational Oncology | 2010年 / 12卷
关键词：
IGF-1 pathway; Review; Anticancer therapy; Monoclonal antibodies; Tyrosine kinase inhibitors;
D O I：
暂无
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学科分类号：
摘要：
The insulin-like growth factor (IGF) system is emerging as a promising new target in cancer therapy. Experimental models and epidemiological studies have demonstrated that the IGF system plays a key role in malignant transformation and cancer progression. Different strategies are being pursued to target this pathway. Several monoclonal antibodies and tyrosine kinase inhibitors targeting the IGF-1 receptor are in clinical development. Early clinical trials indicate these drugs have acceptable safety profiles, and there is pharmacodynamic evidence that actual target inhibition is achievable in patients. Emerging efficacy data as single agent and in combination with chemotherapy is encouraging yet too early for firm conclusions. This manuscript reviews the role of the IGF system in human malignancy and its interactions with other signaling pathways, and summarizes the available data of IGF-1R inhibitors currently in clinical trials.
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页码：326 / 338
页数：12
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