Synthesis of imidazo[4,5-b]pyridines with a chiral substituent at the nitrogen atom and their conversion to piperazine derivatives

被引:0
作者
K. V. Bukhryakov
A. V. Kurkin
M. A. Yurovskaya
机构
[1] M. V. Lomonosov State University,
来源
Chemistry of Heterocyclic Compounds | 2012年 / 48卷
关键词
-butyl imidazo[4,5-; ]pyridine-2-carboxylate; 2-chloro-3-nitropyridine; chiral substituent at a nitrogen atom; nucleophilic substitution; optically active amino acid esters;
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摘要
Imidazopyridine and benzimidazole derivatives have been prepared with chiral substituents at the nitrogen atom and have been converted to the corresponding condensed structures fused with a piperazine ring. A method has been developed for the synthesis of novel class of compounds – 6,7,8,9-tetra-hydropyrido[3',2':4,5]imidazo[1,2-a]pyrazine derivatives.
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页码:773 / 784
页数:11
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