Immediate and delayed cord clamping in infants born between 24 and 32 weeks: A pilot randomized controlled trial

被引：84

作者：

Judith S. Mercer

Margaret M. McGrath

Angelita Hensman

Helayne Silver

William Oh

机构：

[1] College of Nursing, University of Rhode Island, Kingston, RI 02881-2021

[2] Women and Infants' Hospital, Providence, RI

[3] Brown Medical School, Providence, RI

来源：

Journal of Perinatology | 2003年 / 23卷 / 6期

关键词：

D O I：

10.1038/sj.jp.7210970

中图分类号：

学科分类号：

摘要：

Objective: This pilot study's aim was establish feasibility of a protocol for delayed cord clamping (DCC) versus immediate cord clamping (ICC) at preterm birth and to examine its effects on initial blood pressure and other outcomes. Study design: A randomized controlled trial recruited 32 infants between 24 and 32 weeks. Immediately before delivery, mothers were randomized to ICC (cord clamped at 5 to 10 seconds) or DCC (30- to 45-second delay in cord clamping) groups. Results: Intention-to-treat analyses revealed that the DCC group were more likely to have higher initial mean blood pressures (adjusted OR 3.4) and less likely to be discharged on oxygen (adjusted OR 8.6). DCC group infants had higher initial glucose levels (ICC = 36 mg/dl, DCC = 73.1 mg/dl; p = 0.02). Conclusion: The research design is feasible. The immediate benefit of improved blood pressure was confirmed and other findings deserve consideration for further study.

引用

页码：466 / 472

页数：6

共 26 条

[1]

Kinmond S., Aitchison T.C., Holland B.M., Et al., Umbilical cord clamping and preterm infants: A randomized trial, BMJ, 306, pp. 172-175, (1993)

[2]

McDonnell M., Henderson-Smart D.J., Delayed umbilical cord clamping in preterm infants: A feasibility study, J. Paediatr. Child Health, 33, pp. 308-310, (1997)

[3]

Narendra A., Beckett C., Aitchison T., Et al., Is it possible to promote placental transfusion (PTFx) at preterm delivery?, Pediatr. Res., 44, (1998)

[4]

Nelle M., Fischer S., Conze S., Beedgen B., Grischke E.M., Linderkamp O., Effects of late cord clamping on circulation in prematures (VLBWI), Pediatr. Res., 44, (1998)

[5]

Rabe H., Wacker A., Hulskamp G., Hornig-Franz I., Jorch G., Late cord clamping benefits extrauterine adaptation, Pediatr. Res., 44, (1998)

[6]

Rabe H., Wacker A., Hulskamp G., Et al., A randomised controlled trial of delayed cord clamping in very low birth weight preterm infants, Eur. J. Pediatr., 159, 10, pp. 775-777, (2000)

[7]

Ibrahim H.M., Krouskop R.W., Lewis D.F., Dhanireddy R., Placental transfusion: Umbilical cord clamping and preterm infants, J. Perinatol., 20, pp. 351-354, (2000)

[8]

Yao A.C., Moinian M., Lind J., Distribution of blood between the infant and the placenta after birth, Lancet, 2, pp. 871-873, (1969)

[9]

Waldrop C.A.J., Holland B.M., The roles and vital importance of placental blood to the newborn infant, J. Perinat. Med., 23, pp. 139-143, (1995)

[10]

Richardson D.K., Corcoran J.D., Escobar G.J., Lee S.K., SNAP-II and SNAPPE-II: Simplified newborn illness severity and mortality risk scores, J. Pediatr., 138, 1, pp. 92-100, (2001)

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