Preparation and cytotoxic properties of porphysomes based on petroleum porphyrins

An approach to the preparation of porphysomes by the noncovalent immobilization of petroleum porphyrins in the liposome membranes was developed for the first time. Modified nanocontainers with different compositions were prepared in terms of this approach. A composition with doxorubicin optimal in the physicochemical and encapsulation parameters was tested on the M-HeLa cervical cancer cell line and healthy Chang Liver cell line to evaluate the anticancer potential. In order to control the release of the drug substance, remote destruction of the porphysomes was carried out by laser irradiation at 405 nm wavelength. Statistically significant changes in dynamic light scattering data confirming liposome decomposition were obtained for the compositions with 2 and 10 mol.% petroleum porphyrins.