The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses

被引：0
作者：
Sam M. Murray
Azim M. Ansari
John Frater
Paul Klenerman
Susanna Dunachie
Eleanor Barnes
Ane Ogbe
机构：
[1] University of Oxford,Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine
[2] Oxford University Hospitals NHS Foundation Trust,NIHR Oxford Biomedical Research Centre
[3] University of Oxford,Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine
[4] University of Oxford,Mahidol
[5] Mahidol University,Oxford Tropical Medicine Research Unit
来源：
Nature Reviews Immunology | 2023年 / 23卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pre-existing cross-reactive immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins in infection-naive subjects have been described by several studies. In particular, regions of high homology between SARS-CoV-2 and common cold coronaviruses have been highlighted as a likely source of this cross-reactivity. However, the role of such cross-reactive responses in the outcome of SARS-CoV-2 infection and vaccination is currently unclear. Here, we review evidence regarding the impact of pre-existing humoral and T cell immune responses to outcomes of SARS-CoV-2 infection and vaccination. Furthermore, we discuss the importance of conserved coronavirus epitopes for the rational design of pan-coronavirus vaccines and consider cross-reactivity of immune responses to ancestral SARS-CoV-2 and SARS-CoV-2 variants, as well as their impact on COVID-19 vaccination.
引用
收藏
页码：304 / 316
页数：12
相关论文
共 190 条
  • [1] Cui J(2019)Origin and evolution of pathogenic coronaviruses Nat. Rev. Microbiol. 17 181-192
  • [2] Li F(2021)Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19 Cells 89 104490-462
  • [3] Shi Z-L(2021)Genetic comparison among various coronavirus strains for the identification of potential vaccine targets of SARS-CoV2 Infect. Genet. Evol. 584 457-25
  • [4] Yadav R(2020)SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls Nature 222 17-154
  • [5] Kaur N(2020)Epidemiology of seasonal coronaviruses: establishing the context for the emergence of coronavirus disease 2019 J. Infect. Dis. 19 141-93
  • [6] Le Bert N(2021)Characteristics of SARS-CoV-2 and COVID-19 Nat. Rev. Microbiol. 215 108427-47
  • [7] Nickbakhsh S(2020)COVID-19 pathophysiology: a review Clin. Immunol. 6 6317-436
  • [8] Hu B(2021)The isolated effect of age on the risk of COVID-19 severe outcomes: a systematic review with meta-analysis BMJ Glob. Health 11 82-1418
  • [9] Guo H(2020)Ethnicity and clinical outcomes in COVID-19: a systematic review and meta-analysis EclinicalMedicine 9 36-814
  • [10] Zhou P(2020)Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission Nat. Commun. 64 430-1643
12345678910